Beta-lactam - Wikipedia
网页The β-lactam ring is part of the core structure of several antibiotic families, the principal ones being the penicillins, cephalosporins, carbapenems, and monobactams, which are, therefore, also called β-lactam antibiotics. Nearly all of these antibiotics work by inhibiting bacterial cell wall biosynthesis.
Beta-lactam antibiotics - Wikipedia
网页By definition, all β-lactam antibiotics have a β-lactam ring in their structure. The effectiveness of these antibiotics relies on their ability to reach the PBP intact and their ability to bind to the PBP.
Beta-Lactam Antibiotics - StatPearls - NCBI Bookshelf
网页2023年6月4日 · They work primarily by inactivating serine beta-lactamases, which are enzymes that hydrolyze and inactivate the beta-lactam ring (especially in gram-negative bacteria). These agents include the first-generation beta-lactamase inhibitors (clavulanic acid, sulbactam, and tazobactam) and the newer …
Structural Insights for β-Lactam Antibiotics - PMC
网页2023年3月3日 · The structural characteristics of a β-lactam ring provide higher reactivity for β-lactam antibiotics to inactivate penicillin-binding proteins (PBPs) than a linear, five- or six-membered ring and stable benzene ring with conjugated double bonds.
Overview of Beta-Lactams - Overview of Beta-Lactams - The …
网页Beta-lactamases are a diverse class of enzymes produced by bacteria that break open the beta-lactam ring, inactivating the beta-lactam antibiotic. Some beta-lactamases are encoded on mobile genetic elements (eg, plasmids); others are encoded on chromosomes. Beta-lactamase production is among the most clinically important mechanisms of ...
β-Lactams: chemical structure, mode of action and mechanisms of ... - LWW
网页2012年6月20日 · Of the β-lactam antibiotics that are currently available, all feature the reactive β-lactam ring system, a highly strained and reactive cyclic amide. There are five relevant ring systems, including the penam, penem, carbapenem, cefem and …
β-Lactam antibiotic targets and resistance mechanisms: from …
网页2021年10月10日 · β-Lactam antibiotics are frequently administered with a β-lactamase inhibitor (BLI) that protects the antibiotic from SBL-catalyzed degradation. 31–33 The first clinically used BLI, clavulanic acid, contains a β-lactam ring that acylates a nucleophilic serine in the SBL active site (Fig. 1).
Beta-Lactam Ring - an overview | ScienceDirect Topics
网页2012年2月3日 · The β -lactam ring is considered the central motif of the main drugs utilized for the treatment of several bacterial infections such as ampicillin and amoxicillin [14]. The development of efficient and direct methodologies for the synthesis of β -lactams is highly desirable [15–33].
Stereoselective construction of β-, γ- and δ-lactam rings ... - Nature
网页2023年12月6日 · Lactam rings are found in many biologically active natural products and pharmaceuticals, including important classes of antibiotics. Methods for the asymmetric synthesis of these...
β-lactam antibiotics: An overview from a medicinal chemistry ...
网页2020年12月15日 · The β-lactam antibiotics is a family of bactericidal drugs structurally-related containing the β-lactam ring in their chemical structure. They are classified in penicillins, cephalosporins, carbapenems, penems …
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