Carboxylesterase - Wikipedia
网页The enzyme carboxylesterase (or carboxylic-ester hydrolase, EC 3.1.1.1; systematic name carboxylic-ester hydrolase) catalyzes reactions of the following form: [1] a carboxylic ester + H 2 O an alcohol + a carboxylate.
羧酸酯酶（Carboxylesterases, CES）对药物代谢与动力学的影响
网页羧酸酯酶（Carboxylesterases, CES）对药物代谢与动力学的影响. CES主要对包含酯键、酰胺类、氨基甲酸酯和硫代酸酯类结构的药物进行水解作用，尤其对于前药活性成分的释放，或软药（soft drug or antrdrug）的系统循环中活性成分的失活极为重要。. 依据氨基酸序列 …
Human carboxylesterases: a comprehensive review - PMC
网页2018年6月25日 · Human carboxylesterases (CES) play crucial roles in both endo- and xenobiotic metabolism, which arouse great interest in the discovery of potent CES modulators to regulate endobiotic metabolism or to improve the outcomes of ester drugs.
Human carboxylesterases: a comprehensive review - ScienceDirect
网页2018年9月1日 · Mammalian carboxylesterases (CEs) are key enzymes from the serine hydrolase superfamily. In the human body, two predominant carboxylesterases (CES1 and CES2) have been identified and extensively studied over the past decade. These two enzymes play crucial roles in the metabolism of a wide variety of endogenous esters, ester-containing drugs and ...
The role of human carboxylesterases in drug metabolism: have we ...
网页Carboxylesterases are a multi-gene family of enzymes widely distributed throughout the body of mammals that catalyze the hydrolysis of esters, amides, thioesters, and carbamates. In humans, two carboxylesterases, hCE1 and hCE2, are important pathways of drug metabolism.
Carboxylesterase - an overview | ScienceDirect Topics
网页Carboxylesterases are enzymes widely distributed throughout the body of mammals that catalyze the hydrolysis of esters, amides, thioesters, and carbamates.
The Impact of Carboxylesterases in Drug Metabolism and …
网页Carboxylesterases (CESs) are an important class of enzymes for biotransformation of drugs, endogenous substrates, and environmental chemicals that contain esters, amides, carbamates, or thioesters (Table 1). They play a central role in the bioactivation of prodrugs and bioinactivation of soft drugs (or antedrugs).
Carboxylesterases: General detoxifying enzymes - ScienceDirect
网页2016年11月25日 · Carboxylesterase are general detoxifying enzymes that hydrolyze esterified molecules. • They are expressed in tissues likely to be exposed to such agents. • Humans and small mammals demonstrate different levels of carboxylesterase expression. • Organophosphorus compounds are irreversibly inhibitors of these enzymes.
Human carboxylesterases: a comprehensive review - PubMed
网页In the human body, two predominant carboxylesterases (CES1 and CES2) have been identified and extensively studied over the past decade. These two enzymes play crucial roles in the metabolism of a wide variety of endogenous esters, ester-containing drugs and environmental toxicants.
THE MAMMALIAN CARBOXYLESTERASES: From Molecules to …
网页Multiple carboxylesterases (EC 3.1.1.1) play an important role in the hydrolytic biotransformation of a vast number of structurally diverse drugs. These enzymes are major determinants of the pharmacokinetic behavior of most therapeutic agents containing ester or …