CD38 - Wikipedia
网页CD38 (cluster of differentiation 38), also known as cyclic ADP ribose hydrolase, is a glycoprotein [5] found on the surface of many immune cells (white blood cells), including CD4 +, CD8 +, B lymphocytes and natural killer cells. CD38 also functions in cell adhesion, signal transduction and calcium signaling. [6]
CD38靶点简介：具有免疫抑制作用的特异性蛋白 - 知乎
网页CD38蛋白的功能及酶活. CD38（Cluster of Differentiation 38）于1980年被科学家E.L. Reinherz和S.F. Schlossman等人发现。. 当时的研究认为CD38是T细胞激活的特异性marker，而对其生物学功能则没有进行过多的研究。. 后来的研究过程中， CD38功能的谜团被逐步揭开，研究人员最终 ...
CD38: An Immunomodulatory Molecule in Inflammation and …
网页2020年11月30日 · CD38 was originally identified as a protein expressed on the surface of T cells but nowadays, we know that CD38’s function goes beyond a single cell or serving as a simple molecular marker. Indeed, CD38 plays critical roles in human physiology by modulating homeostasis, inflammation, or autoimmune responses in our body.
CD38: A Significant Regulator of Macrophage Function
网页2022年2月17日 · The present review discusses the effects of CD38 expression on the proliferation and polarization of macrophages, the effect of CD38 on macrophage function and its possible mechanisms, the expression level of CD38 on macrophage surfaces related to disease diagnosis, treatment, and prognosis; and the role of …
Roles of CD38 in the Immune Response to Infection - PMC
网页2020年1月16日 · CD38 expression is up-regulated by an array of inflammatory mediators, and it is frequently used as a cell activation marker. Studies in animal models indicate that CD38 functional expression confers protection against infection by several bacterial and parasitic pathogens.
CD38: An important regulator of T cell function - PubMed
网页In this paper, we reviewed the role and mechanism of CD38 + CD4 + T cells / CD38 + CD8 + T cells in cellular immunity and the effects of the CD38-NAD + axis on T cell activity. We also summarized the relationship between the CD38 expression level on T cell surface and disease prediction and prognosis, the effects of anti-CD38 monoclonal ...
Evolving roles of CD38 metabolism in solid tumour …
网页2022年7月11日 · CD38 is a transmembrane protein that is widely expressed in immune cells and serves as a marker of hematopoietic cell differentiation [1]. CD38 is involved in the regulation of immune cell...
Roles of CD38 in the Immune Response to Infection - PubMed
网页2020年1月16日 · CD38 expression is up-regulated by an array of inflammatory mediators, and it is frequently used as a cell activation marker. Studies in animal models indicate that CD38 functional expression confers protection against infection by several bacterial and parasitic pathogens.
Frontiers | The Multi-faceted Ecto-enzyme CD38: Roles in ...
网页CD38 (Cluster of Differentiation 38) is a multifunctional ecto-enzyme that metabolizes NAD+ and mediates nicotinamide dinucleotide (NAD+) and extracellular nucleotide homeostasis as well as intracellular calcium. CD38 is also an emerging therapeutic target under conditions in which metabolism is altered including infection, aging, and ...
CD38: an ecto-enzyme with functional diversity in T cells
网页2023年4月26日 · CD38, a nicotinamide adenine dinucleotide (NAD)+ glycohydrolase, is considered an activation marker of T lymphocytes in humans that is highly expressed during certain chronic viral infections. T cells constitute a heterogeneous population; however, the expression and function of CD38 has been poorly defined in distinct T cell compartments.
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