攻克CD40/CD40L，曙光已现 - 知乎 - 知乎专栏
网页CD40L是CD40的天然三聚体配体，为一种39kDa的II型跨膜蛋白，其在多种细胞类型上表达。 CD40L的表达通常是可诱导的， 并局限于造血系统的细胞 （如血小板、粒细胞、活化T细胞、活化B细胞和活化自然杀伤细胞）和部分肿瘤细胞等。 CD40-CD40L是一对共刺激分子，在细胞表面相互作用后，CD40胞内结构域募集TNFR相关因子 (TRAF)促进细胞内信号传导，从而激活不同的信号通路，参与机体免疫反应，已被鉴定可调节广泛的细胞反应，包 …
Molecular mechanism and function of CD40/CD40L engagement …
网页A wide spectrum of molecular and cellular processes is regulated by CD40 engagement including the initiation and progression of cellular and humoral adaptive immunity. In this review, we describe the downstream signaling pathways initiated by CD40 and overview how CD40 engagement or antagonism modulates humoral and cellular immunity.
CD40 (protein) - Wikipedia
网页Cluster of differentiation 40, CD40 is a type I transmembrane protein found on antigen-presenting cells and is required for their activation. The binding of CD154 (CD40L) on T H cells to CD40 activates antigen presenting cells and induces a variety of downstream effects.
Molecular basis and therapeutic implications of CD40/CD40L …
网页The CD40 receptor and its ligand CD40L is one of the most critical molecular pairs of the stimulatory immune checkpoints. Both CD40 and CD40 L have a membrane form and a soluble form generated by proteolytic cleavage or alternative splicing.
Molecular basis and therapeutic implications of CD40/CD40L …
网页This review provides a comprehensive overview of the structure, processing, cellular expression pattern, signaling and effector function of CD40/CD40L checkpoint molecules. In addition, we summarize the progress, targeted diseases and outcomes of current ongoing and completed clinical trials of CD40/CD40L-targeted therapy.
Cell-specific and divergent roles of the CD40L-CD40 axis in ... - Nature
网页2021年6月18日 · As CD40L exerts multiple functions depending on the cell-cell interactions involved, we sought to investigate the function of the most relevant CD40L-expressing cell types in atherosclerosis: T...
Molecular mechanism and function of CD40/CD40L engagement in ... - PubMed
网页In this review, we describe the downstream signaling pathways initiated by CD40 and overview how CD40 engagement or antagonism modulates humoral and cellular immunity. Lastly, we discuss the role of CD40 as a target in harnessing anti-tumor immunity.
Molecular basis and therapeutic implications of CD40/CD40L …
网页2021年3月1日 · CD40/CD40L immune checkpoint leads to activation of both innate and adaptive immune cells via two-way signaling. CD40/CD40L interaction also participates in regulating thrombosis, tissue inflammation, hematopoiesis and tumor cell fate.
CD40 signal rewires fatty acid and glutamine metabolism for
网页2023年2月23日 · Here we show that CD40 activation triggers fatty acid oxidation (FAO) and glutamine metabolism to promote ATP citrate lyase-dependent epigenetic reprogramming of pro-inflammatory genes and anti...
CD40/CD40L signaling and its implication in health and disease
网页2009年11月10日 · The interaction between CD40 and CD40 ligand (CD40L) enhances the expression of cytokines, chemokines, matrix metalloproteinases, growth factors, and adhesion molecules, mainly through the stimulation of nuclear factor kappa B.
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