Molecular mechanism and function of CD40/CD40L engagement …
网页A wide spectrum of molecular and cellular processes is regulated by CD40 engagement including the initiation and progression of cellular and humoral adaptive immunity. In this review, we describe the downstream signaling pathways initiated by CD40 and overview how CD40 engagement or antagonism modulates humoral and cellular immunity.
Targeting the CD40-CD40L pathway in autoimmune diseases: Humoral ...
网页2019年2月15日 · Interactions between B cell-expressed CD40 and its binding partner, CD40L, predominantly expressed on activated CD4+ T cells, play a critical role in promoting germinal center formation and the production of class-switched antibodies. Non-hematopoietic cells expressing CD40 can also engage CD40L and trigger a pro-inflammatory response.
Molecular basis and therapeutic implications of CD40/CD40L …
网页CD40/CD40L signal pathways. The ligation of trimeric mCD40 with mCD40L or sCD40L results in the recruitment of signal molecules TRAFs to CD40 cytoplasmic domain. CD40 cytoplasmic domain contains two distinct TRAF binding sites. TRAF1, TRAF2, TRAF3 and TRAF5 bind competitively to one site and TRAF6 binds to another.
Cell-specific and divergent roles of the CD40L-CD40 axis in ... - Nature
网页2021年6月18日 · We show that the T cell-DC CD40L-CD40 plays a role in plaque progression and stability via the Th1-associated IFN-γ pathway while platelet CD40L regulates atherothrombosis.
Targeting the CD40-CD40L pathway in autoimmune diseases: …
网页2019年2月15日 · Interactions between B cell-expressed CD40 and its binding partner, CD40L, predominantly expressed on activated CD4+ T cells, play a critical role in promoting germinal center formation and the production of class-switched antibodies. Non-hematopoietic cells expressing CD40 can also engage CD40L and trigger a pro-inflammatory response.
Inhibition of CD40L with Frexalimab in Multiple Sclerosis
网页2024年2月14日 · Inhibition of the binding of CD40L to CD40 expressed on the surface of antigen-presenting cells disrupts the CD40–CD40L signaling pathway and can prevent T-cell–mediated immune response.
A CD40L-targeting protein reduces autoantibodies and improves …
网页2019年4月24日 · The CD40/CD40L pathway plays a critical role in driving humoral immune responses and has been implicated in the pathogenesis of several autoimmune diseases. CD40 is constitutively expressed on a variety of antigen-presenting cells—including dendritic cells, macrophages, and B cells —but can also be expressed on nonhematopoietic cells.
Molecular basis and therapeutic implications of CD40/CD40L …
网页The canonical CD40/CD40L signaling is mediated by recruitment of TRAFs and NF-κB activation, which is supplemented by signal pathways such as PI3K/AKT, MAPKs and JAK3/STATs. CD40/CD40L immune checkpoint leads to activation of both innate and adaptive immune cells via two-way signaling.
Molecular mechanism and function of CD40/CD40L engagement in ... - PubMed
网页A wide spectrum of molecular and cellular processes is regulated by CD40 engagement including the initiation and progression of cellular and humoral adaptive immunity. In this review, we describe the downstream signaling pathways initiated by CD40 and overview how CD40 engagement or antagonism modulates humoral and cellular immunity.
Oncolytic adenovirus encoding decorin and CD40 ligand
网页2 天之前 · CD40-CD40L, an important costimulatory signaling pathway, participates in the activation of both humoral and cellular immunity. Both CD40 specific agonist antibody and recombinant soluble CD40 Ligand (CD40L) protein can effectively activate anti-tumor immune response in pre-clinical animal models [ 20 , 21 , 22 ].
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