DSG4 Gene - GeneCards | DSG4 Protein | DSG4 Antibody
网页2024年8月5日 — This gene encodes a member of the desmoglein subgroup of desmosomal cadherins. The encoded preproprotein is proteolytically processed to generate the mature protein. This protein is a transmembrane component of desmosomes and may play a role in cell-cell adhesion in epithelial cells.
DSG4 gene - MedlinePlus
网页The DSG4 gene provides instructions for making a protein called desmoglein 4 (DSG4). This protein is found in specialized structures called desmosomes that are located in the membrane surrounding certain cells. Desmosomes help attach cells to one another and play a role in communication between cells.
桥粒芯糖蛋白表达和功能异常相关疾病及药物干预作用研究进展
网页桥粒芯糖蛋白4(desmoglein 4，DSG4) 主要分布于皮肤及毛发中，在皮肤中特异性表达在表皮的毛干皮层、角质层、内根皮层角质层和颗粒层中；在毛发中表达在发根皮层、下头发角质层和上内根鞘中。
Autosomal recessive monilethrix: Novel variants of the DSG4 gene …
网页2022年2月11日 — In humans, coding genes for four DSG (DSG1‐DSG4) and three DSC (DSC1‐DSC3) have been identified on chromosome 18q12.2. They play a critical role in intercellular adhesion and keratinocyte differentiation. The human DSG4 gene encodes DSG4, a new member of the cadherin superfamily.
桥粒芯糖蛋白 4（DSG4）基因 | MCE - MCE-生物活性分子大师
网页功能概要. 该基因编码桥粒钙粘蛋白桥粒芯糖蛋白亚组的成员。. 编码的前原蛋白经过蛋白水解处理以生成成熟蛋白。. 这种蛋白质是桥粒的跨膜成分，可能在上皮细胞的细胞间粘附中发挥作用。. 该基因的突变与局部常染色体隐性遗传性少毛症和单发毛发有关 ...
1. 桥粒芯蛋白家族DSGs - 华美生物
网页2023年5月15日 — 桥粒芯蛋白家族（Desmogleins，DSGs）作为细胞表面跨膜蛋白，是组成细胞紧密连接—桥粒结构的重要部分。 桥粒芯蛋白家族DSGs共有4种亚型（DSG1 、DSG2、 DSG3 、DSG4），与桥粒胶蛋白家族（Desmocollins，DSCs）的3种亚型（DSC1 、 DSC2 、 DSC3）一起组成了桥粒钙黏素家族。 这些蛋白与桥粒斑蛋白DSP等共同构成细胞黏附结构—桥粒或半桥粒，其中桥粒芯蛋白家族DSGs作为关键蛋白，调节相邻细胞间 …
DSG4 desmoglein 4 [Homo sapiens (human)] - Gene - NCBI
网页2024年3月5日 — Title: A novel deletion mutation in the DSG4 gene underlies autosomal recessive hypotrichosis with variable phenotype in two unrelated consanguineous families. Genetic analysis of striate palmoplantar keratoderma and hypotrichosis identified their responsible genes as desmogleins 1 and 4, respectively.
DSG4 protein expression summary - The Human Protein Atlas
网页The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Cell type enhanced (Early spermatids) Single cell type.
147409 - Gene ResultDSG4 desmoglein 4 [ (human)] - National …
网页2023年11月23日 — A large, intragenic deletion in the desmoglein 4 gene (DSG4) is the underlying mutation in an autosomal recessive form of hypotrichosis. This gene encodes a member of the desmoglein subgroup of desmosomal cadherins. The encoded preproprotein is proteolytically processed to generate the mature protein. This protein is a …
DSG4 Gene - maayanlab.cloud
网页DSG4 Gene. Functional Associations. DSG4 has 1,944 functional associations with biological entities spanning 8 categories (molecular profile, organism, functional term, phrase or reference, disease, phenotype or trait, chemical, structural feature, cell line, cell type or tissue, gene, protein or microRNA) extracted from 63 datasets.
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