Doxofylline - Wikipedia
网页Doxofylline (also known as doxophylline) is a phosphodiesterase inhibiting bronchodilator used in the treatment of chronic respiratory diseases such as asthma [1] and COPD. [2] Like theophylline , it is a xanthine derivative.
Doxofylline: Uses, Interactions, Mechanism of Action - DrugBank …
网页Doxofylline is a methylxanthine bronchodilator with potent bronchodilator activity comparable to that of theophylline. In animal studies, doxofylline demonstrated to attenuate bronchoconstriction, inflammatory actions and the release of thromboxane A2 (TXA2) when challenged with platelet-activating factor 9.
Doxofylline: Uses, Dosage, Side Effects and More - MIMS
网页Doxofylline: Belongs to the class of xanthines. Used in the systemic treatment of obstructive airway diseases. Our drug directory offers in-depth details on its uses, side effects, and more. Get the latest medication information and prescription drug insights today!
Doxofylline - an overview | ScienceDirect Topics
网页Doxofylline (7- (1,3-dioxolan-2-ylmethyl)-3,7-dihydro-l, 3 dimethyl-lH-purine-2,6-dione) is a newer generation xanthine with both bronchodilating and anti-inflammatory activities and for this reason it has been called “novofylline” [13].
Doxofylline is not just another theophylline! - PMC
网页2017年12月5日 · Doxofylline, chemically known as 7- (1,3-dioxolan-2-ylmethyl)-3,7-dihydro-l,3 dimethyl-lH-purine-2,6-dione, is a xanthine derivative having both anti-inflammatory and bronchodilating activities. It differs from theophylline in …
Efficacy and safety profile of doxofylline compared to …
网页2019年8月3日 · The novel methylxanthine doxofylline, that has bronchodilator and anti-inflammatory activities, is not affected by the major drawback of theophylline. Nowadays large-scale quantitative synthesis comparing the efficacy and safety profile of doxofylline vs. theophylline in the treatment of asthma is still lacking.
The effect of doxofylline in asthma and COPD - Respiratory …
网页2019年11月18日 · It was shown that concomitant treatment with a low dose of doxofylline and a low dose of dexamethasone (that alone had no effect) significantly reduced allergen-induced eosinophil infiltration into the lungs of allergic mice and LPS-induced neutrophil pulmonary infiltration in healthy animals [19].
A long-term clinical trial on the efficacy and safety profile of ...
网页2020年2月1日 · Doxofylline, an oral methylxanthine with bronchodilator and anti-inflammatory activities, offers a promising alternative to theophylline due to its superior efficacy/safety profile. No long-term studies on the efficacy and safety of doxofylline are currently available in asthma.
Doxofylline | C11H14N4O4 | CID 50942 - PubChem
网页Doxofylline is an oxopurine that is a derivative of xanthine, methylated at N-1 and N-3 and carrying a 1,3-dioxolan-2-ylmethyl group at N-7, used in the treatment of asthma. It has a role as a bronchodilator agent, an antitussive and an anti-asthmatic drug. It is functionally related to a 7H-xanthine. ChEBI.
Doxofylline for Pediatric Asthma Steps 1–4. Pediatric Asthma: …
网页2022年6月22日 · In this review, we will re-assess the role of doxofylline, a xanthine characterized by a much higher handling than that of theophylline, as add-on treatment in pediatric asthma grade 1–4. Ten studies evaluated doxofylline in the treatment of asthma of patients non-responsive to the first-line inhaled corticosteroids.
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