Doxofylline - Wikipedia
网页Doxofylline (also known as doxophylline) is a phosphodiesterase inhibiting bronchodilator used in the treatment of chronic respiratory diseases such as asthma [1] and COPD. [2] Like theophylline , it is a xanthine derivative.
Doxofylline: Uses, Interactions, Mechanism of Action - DrugBank …
网页Doxofylline is a methylxanthine bronchodilator with potent bronchodilator activity comparable to that of theophylline. In animal studies, doxofylline demonstrated to attenuate bronchoconstriction, inflammatory actions and the release of thromboxane A2 (TXA2) when challenged with platelet-activating factor 9.
Doxofylline: Uses, Dosage, Side Effects and More - MIMS
网页Mechanism of Action: Doxofylline, a theophylline derivative, is a bronchodilator. It inhibits phosphodiesterase enzymes which increase cyclic adenine monophosphate (cAMP), thereby causing bronchial smooth muscle relaxation leading to bronchodilation. Absorption: Rapidly absorbed.
Doxofylline is not just another theophylline! - PMC
网页2017年12月5日 · Doxofylline, which differs from theophylline in containing the dioxalane group at position 7, has comparable efficacy to theophylline in the treatment of respiratory diseases, but with an improved tolerability profile and a favorable risk-to-benefit ratio.
Efficacy and safety profile of doxofylline compared to …
网页2019年8月3日 · The novel methylxanthine doxofylline, that has bronchodilator and anti-inflammatory activities, is not affected by the major drawback of theophylline. Nowadays large-scale quantitative synthesis comparing the efficacy and safety profile of doxofylline vs. theophylline in the treatment of asthma is still lacking.
Doxofylline - an overview | ScienceDirect Topics
网页Doxofylline is a newer generation xanthine with both bronchodilating and anti-inflammatory activities and for this reason it has been called “novofylline”. It differs substantially from theophylline at the pharmacological level.
To Study the Efficacy and Safety of Doxophylline and …
网页2015年4月1日 · Doxophylline has emerged as one such drug; studied in animals as well as in human adults and children with obstructive air way diseases have found it to be effective and safe with efficacy similar to theophylline .
Doxofylline: A “Novofylline” - ScienceDirect
网页2010年8月1日 · Doxofylline is a xanthine molecule that appears to be both bronchodilator and anti-inflammatory with an improved therapeutic window over conventional xanthines such as theophylline and the evidence supporting the effects of doxofylline in the treatment of lung diseases is discussed.
Doxofylline: a "novofylline" - PubMed
网页Doxofylline is a xanthine molecule that appears to be both bronchodilator and anti-inflammatory with an improved therapeutic window over conventional xanthines such as theophylline and the evidence supporting the effects of doxofylline in the treatment of lung diseases is discussed.
Effects of doxofylline as an adjuvant on severe exacerbation and …
网页As an adjuvant drug, doxofylline has a good therapeutic effect on patients with the neutrophilic and eosinophilic clinical subtypes of COPD. It can reduce the incidence of severe exacerbation, the use of glucocorticoids, and inflammatory reactions in the long term (when used for a minimum of 3 months).
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