Fibroblast growth factor 23 - Wikipedia
网页Fibroblast growth factor 23 (FGF-23) is a protein and member of the fibroblast growth factor (FGF) family which participates in the regulation of phosphate in plasma and vitamin D metabolism. In humans it is encoded by the FGF23 gene. FGF-23 decreases reabsorption of phosphate in the kidney.
Biology of Fibroblast Growth Factor 23: From Physiology to …
网页Fibroblast growth factor (FGF)23 is a phosphaturic hormone produced by osteocytes and osteoblasts that binds to FGF receptors in the presence of the transmembrane protein αKlotho. FGF23 mainly targets the renal proximal tubule to inhibit calcitriol production and the expression of the sodium/phosphate cotransporters NaPi2a and NaPi2c, thus ...
成纤维细胞生长因子23（Fibroblast growth factor,FGF23）
网页2023年4月20日 · 成纤维细胞生长因子23（Fibroblast growth factor,FGF23）是近年来明确的磷调节激素。主要由骨骼中骨细胞合成分泌，少数由成骨细胞和软骨细胞分泌。FGF23最初发现于常染色体显性遗传低磷软骨病（ADHR），后来在肿瘤导致骨软化病和X伴性低磷软骨病中被进一步研究。
FGF23: A Review of Its Role in Mineral Metabolism and Renal and ...
网页2021年5月17日 · FGF23 is a circulating endocrine hormone that plays a regulating role in mineral metabolism. Increases in FGF23 concentrations occur as a physiological response to maintain normal serum phosphate levels by inducing renal phosphate excretion.
Fibroblast Growth Factor 23 - an overview | ScienceDirect Topics
网页Fibroblast Growth Factor 23 (FGF23) is a member of the fibroblast growth factor family that acts as an endocrine regulator by influencing cell growth, differentiation, and metabolism.
FGF23 Signalling and Physiology - PMC - National Center for ...
网页2022年2月2日 · Fibroblast growth factor 23 (FGF23) is a phosphotropic hormone that belongs to a subfamily of endocrine FGFs with evolutionarily conserved functions in C. elegans and fruit flies. FAM20C phosphorylates FGF23 post-translationally, targeting to proteolysis through subtilisin-like proprotein convertase FURIN, resulting in secretion of FGF23 fragments.
Regulation of FGF23 production and phosphate metabolism by
网页2023年1月9日 · The bone-derived hormone fibroblast growth factor 23 (FGF23) functions in concert with parathyroid hormone (PTH) and the active vitamin D metabolite, 1,25...
Renal and extrarenal effects of fibroblast growth factor 23
网页2018年12月4日 · Fibroblast growth factor 23 (FGF23) is a hormone with a central role in the regulation of phosphate homeostasis. This regulation is accomplished by the...
Fibroblast Growth Factor 23 - an overview | ScienceDirect Topics
网页Fibroblast growth factor (FGF)-23 is a bone-derived hormone that contributes to maintain the mineral homeostasis by inducing urine elimination and lowering intestinal absorption of phosphate, and by reducing active vitamin D level. 80 FGF-23 level is regulated by calcium/phosphate modulators such as vitamin D and PTH.
FGF23 signalling and physiology - PubMed
网页Fibroblast growth factor 23 (FGF23) is a phosphotropic hormone that belongs to a subfamily of endocrine FGFs with evolutionarily conserved functions in worms and fruit flies. FAM20C phosphorylates FGF23 post-translationally, targeting it to proteolysis through subtilisin-like proprotein convertase FURIN, resulting in secretion of FGF23 fragments.