Leucovorin Uses, Side Effects & Warnings - Drugs.com
网页2024年7月29日 · What is leucovorin? Leucovorin is a form of folic acid. Folic acid helps your body produce and maintain new cells, and also helps prevent changes to DNA that may lead to cancer. Folic acid is present in many foods such as dried beans, peas, oranges, spinach, and others.
Folinic Acid - StatPearls - NCBI Bookshelf - National Center for ...
网页2024年2月28日 · Folinic acid, also known as 5-formyl tetrahydrofolic acid or leucovorin, treats various cancers when employed with 5-fluorouracil (5-FU). Additionally, leucovorin serves as an antidote to folic acid antagonists like methotrexate.
Folinic acid - Wikipedia
网页Folinic acid, also known as leucovorin, is a medication used to decrease the toxic effects of methotrexate and pyrimethamine. [2][3] It is also used in combination with 5-fluorouracil to treat colorectal cancer and pancreatic cancer, may be used to treat folate deficiency that results in anemia, and methanol poisoning. [3][4] It is taken by mout...
Leucovorin: Uses, Interactions, Mechanism of Action
网页Leucovorin is one of several active, chemically reduced derivatives of folic acid. It is useful as an antidote to drugs which act as folic acid antagonists. Leucovorin is a mixture of the diastereoisomers of the 5-formyl derivative of tetrahydrofolic acid (THF).
Folinic acid (leucovorin or calcium folinate)
网页Folinic acid is also known as calcium folinate or leucovorin. It is used to make chemotherapy work better, or to reduce its side effects. Learn more about it.
Leucovorin - StatPearls - NCBI Bookshelf
网页2023年7月3日 · Leucovorin is a 5-formyl derivative of folic acid, used in biochemical reactions without having to undergo reduction. Leucovorin is FDA indicated after high dose methotrexate therapy in osteosarcoma to decrease the toxic effects of methotrexate or counter the toxic effects of folate antagonists.
Folic Acid, Folinic Acid, 5 Methyl TetraHydroFolate …
网页2022年1月24日 · Folinic acid (Leucovorin) is also a synthetic molecule, a 5-formyl derivative of THF that is readily converted to 5–10 MTHF and 5-MTHF without requiring the action of DHFR. It is used to decrease the toxic effects of chemotherapeutic agents that interfere with folate metabolism by inhibiting DHFR (e.g., …
Levoleucovorin: Uses, Interactions, Mechanism of Action
网页2016年5月19日 · Levoleucovorin is the enantiomerically active form of Folinic Acid (also known as 5-formyl tetrahydrofolic acid or leucovorin). Commercially available leucovorin is composed of a 1:1 racemic mixture of the dextrorotary and levorotary isomers, while levoleucovorin contains only the pharmacologically active levo-isomer.
Folinic Acid - PubMed
网页2024年2月28日 · Folinic acid, also known as 5-formyl tetrahydrofolic acid or leucovorin, treats various cancers when employed with 5-fluorouracil (5-FU). Additionally, leucovorin serves as an antidote to folic acid antagonists like methotrexate.
Leucovorin (folinic acid) rescue for high-dose methotrexate: A
网页Leucovorin rescue is a cornerstone for toxicity prevention in HDMTX treatment. However, the leucovorin dose adjustment and the existence of leucovorin overrescue are still controversial. At present, various methods for calculating leucovorin doses in different tumour types have been proposed, including empirical calculations based on MTX plasma ...