GNAQ - Wikipedia
网页Guanine nucleotide-binding proteins are a family of heterotrimeric proteins that couple cell surface, 7-transmembrane domain receptors to intracellular signaling pathways. Receptor activation catalyzes the exchange of GDP for GTP bound to the inactive G protein alpha subunit resulting in a conformational change and dissociation of the complex.
GNAQ Gene - GeneCards | GNAQ Protein | GNAQ Antibody
网页2024年8月6日 · GNAQ (G Protein Subunit Alpha Q) is a Protein Coding gene. Diseases associated with GNAQ include Sturge-Weber Syndrome and Capillary Malformations, Congenital . Among its related pathways are Thromboxane signalling through TP receptor and Development Angiotensin activation of ERK .
GNAQ gene - MedlinePlus
网页The GNAQ gene provides instructions for making a protein called guanine nucleotide-binding protein G (q) subunit alpha (Gαq). Learn about this gene and related health conditions.
GNAQ and GNA11 Genes: A Comprehensive Review on …
网页2022年6月22日 · The GNAQ and GNA11 genes are involved in various signalling pathways that are essential for the proliferation of tumoral cells in UM. This, in combination with its high mutational rate of these tumours, makes them promising targets and regulators of the therapeutic response in UM.
Sturge–Weber Syndrome and Port-Wine Stains Caused by Somatic …
网页2013年5月23日 · The Sturge–Weber syndrome is a sporadic congenital neurocutaneous disorder characterized by a port-wine stain affecting the skin in the distribution of the ophthalmic branch of the trigeminal...
Neuronal activation of Gαq EGL-30/GNAQ late in life rejuvenates ...
网页We found that activation of EGL-30 in aged worms triples memory span, and GNAQ gain of function significantly improved memory in aged mice: GNAQ (gf) in hippocampal neurons of 24-month-old mice (equivalent to 70- to 80-year-old humans) rescued age-related impairments in well-being and memory.
Targeting GNAQ/11 through PKC inhibition in uveal melanoma
网页2022年2月18日 · GNAQ/11 mutations are present in over 90% of patients with uveal melanoma and lead to signal transduction through G-protein coupled receptors to downstream growth factors.
G-Protein αq (GNAQ) | SpringerLink
网页2018年1月1日 · The official gene symbol for Gα q in Homo sapiens and other mammals is GNAQ (guanine nucleotide-binding protein alpha q). GNAQ is the prototypical member of a G-protein family formed by GNAQ, GNA11, GNA14, and GNA15.
GNAQ G protein subunit alpha q [ (human)] - National Center for ...
网页GNAQ G protein subunit alpha q [ (human)] Gene ID: 2776, updated on 17-Mar-2024. Summary. This locus encodes a guanine nucleotide-binding protein. The encoded protein, an alpha subunit in the Gq class, couples a seven-transmembrane domain receptor to activation of phospolipase C-beta.
Gnaq guanine nucleotide binding protein, alpha q polypeptide …
网页2024年5月12日 · Gnaq guanine nucleotide binding protein, alpha q polypeptide [ (house mouse)] Gene ID: 14682, updated on 12-May-2024. Summary. Predicted to enable several functions, including G-protein beta/gamma-subunit complex binding activity; GTPase activator activity; and alkylglycerophosphoethanolamine phosphodiesterase activity.