IGFBP-6: At the Crossroads of Immunity, Tissue Repair and Fibrosis
网页2022年4月14日 · Insulin-like growth factors binding protein-6 (IGFBP-6) is involved in a relevant number of cellular activities and represents an important factor in the immune response, particularly in human dendritic cells (DCs). Over the past several years, significant insights into the IGF-independent effects of IGFBP-6 …
IGFBP-6: At the Crossroads of Immunity, Tissue Repair and Fibrosis
网页2022年4月14日 · This review aims at describing the current understanding of mechanisms that link IGFBP-6 and fibrosis development and at highlighting the multiple roles of IGFBP-6 to provide an insight into evolutionarily conserved mechanisms that can be relevant for inflammation, tumor immunity, and immunological diseases.
IGFBP-6: At the Crossroads of Immunity, Tissue Repair and …
网页2022年4月14日 · This review aims at describing the current understanding of mechanisms that link IGFBP-6 and fibrosis development and at highlighting the multiple roles of IGFBP-6 to provide an insight into evolutionarily conserved mechanisms that can be relevant for inflammation, tumor immunity, and immunological diseases.
IGFBP6 Gene - GeneCards | IBP6 Protein | IBP6 Antibody
网页2024年8月6日 · IGFBP6 (Insulin Like Growth Factor Binding Protein 6) is a Protein Coding gene. Diseases associated with IGFBP6 include Insulin-Like Growth Factor I and Acth-Secreting Pituitary Adenoma.
Recent insights into the actions of IGFBP-6 - PubMed
网页IGFBP-6 is an O-linked glycoprotein that preferentially binds IGF-II over IGF-I. It is a relatively selective inhibitor of IGF-II actions including proliferation, survival and differentiation of a wide range of cells. IGFBP-6 has recently been shown to have a number of IGF-independent actions, inclu ….
IGF binding proteins in cancer: mechanistic and clinical insights
网页2014年4月10日 · The stimulation of rhabdomyosarcoma cell migration by IGFBP-6 was shown to require cell surface interaction with prohibitin 2, a protein found in the mitochondria and nucleus, as well as in the...
From fever to immunity: A new role for IGFBP-6? - PubMed
网页Importantly, in this context, we highlight the novel regulatory functions discovered for IGFBP-6 protein: induction of chemotaxis; capacity to increase oxidative burst and degranulation of neutrophils, ability to induce metabolic changes in DCs.
Current ideas on the biology of IGFBP-6: More than an IGF-II inhibitor ...
网页2016年10月1日 · IGFBP-6 is a relatively specific inhibitor of IGF-II actions. • IGFBP-6 also has IGF-independent effects on proliferation, survival, differentiation and migration. • IGFBP-6 binds to several ligands in the extracellular space, cytoplasm and nucleus. • These interactions may contribute to its IGF-independent actions.
Recent insights into the actions of IGFBP-6 | Journal of Cell ...
网页2015年3月26日 · IGFBP-6 has recently been shown to have a number of IGF-independent actions, including promotion of apoptosis in some cells and inhibition of angiogenesis. IGFBP-6 also induces migration of tumour cells including rhabdomyosarcomas by an IGF-independent mechanism. This chemotactic effect is mediated by MAP kinases.
Structural basis for assembly and disassembly of the IGF/IGFBP…
网页2022年7月30日 · Six members of the human IGFBP family (IGFBP1–6) consist of N-terminal, central linker, and C-terminal domains. The central linker domain (CLD), a major proteolytic site for IGF...