Insulin-Like Growth Factor-1 (IGF-1) and Its Monitoring in …
网页2021年2月4日 · Insulin-like growth factor-2 (IGF-2) is a protein closely related to IGF-1 and capable of binding to the IGF-1R as well as its own IGF-2 receptor (IGF-2R). However, whilst the IGF-1R is capable of signal transduction, the IGF-2R is not and binding results in lysosomal degradation of IGF-2.
Insulin-like growth factor - Wikipedia
网页Insulin-like growth factor 2 (IGF-2, at times IGF-II) is thought to be a primary growth factor required for early development while IGF-1 expression is required for achieving maximal growth. Gene knockout studies in mice have confirmed this, though other animals are likely to regulate the expression of these genes in distinct ways.
Insulin-like growth factors: Ligands, binding proteins, and receptors
网页2021年5月4日 · The insulin-like growth factor family of ligands (IGF-I, IGF-II, and insulin), receptors (IGF-IR, M6P/IGF-IIR, and insulin receptor [IR]), and IGF-binding proteins (IGFBP-1-6) play critical roles in normal human physiology and disease states.
Understanding IGF-II Action through Insights into Receptor …
网页2020年10月12日 · IGF-II contacts the receptor through two surfaces originally defined by site-directed mutagenesis that are named site 1 and site 2. Equivalent residues of IGF-I and insulin are involved in binding IGF-1R and IR, respectively (Table 1).
Insulin‐like growth factor‐II: its role in metabolic and endocrine ...
网页2014年3月5日 · About 75% of serum IGFs are contained in IGF-ALS-IGFBP-3 ternary complexes. IGFs exert their biological effects by binding to the type 1 IGF receptor (IGF-1R) and insulin receptor (IR). Hybrid receptors of IGF-1R and IR also bind IGFs (not shown). The type 2 IGF receptor (IGF-2R) binds IGF-II alone.
The insulin-like growth factor type 1 and insulin-like growth factor ...
网页2007年9月7日 · We recently reported that IGF-1 and IGF-2 stimulate the ERK1/2 cascade by triggering sphingosine kinase-dependent "transactivation" of G protein-coupled sphingosine-1-phosphate receptors. To determine which IGF receptors mediate this effect, we tested seven insulin family peptides, IGF-1, IGF-2, …
IGF 1 and IGF 2 | SpringerLink
网页2016年1月1日 · Insulin-like growth factor-1 (IGF-1) and IGF-2 are circulating peptide growth factor hormones important in normal growth and development. Their biological effects are mediated by specific cell surface receptors, the type I IGF receptor (IGF1R) and the insulin receptor.
Structural basis of the activation of type 1 insulin-like ... - Nature
网页2019年10月8日 · Type 1 insulin-like growth factor receptor (IGF1R) is a receptor tyrosine kinase that regulates cell growth and proliferation, and can be activated by IGF1, IGF2,...
Mechanisms of Disease: metabolic effects of growth hormone …
网页Insulin-like growth factor (IGF) 1 is a member of a family that is involved in growth, development, cell differentiation, and metabolism. IGF1, IGF2 and insulin act primarily through...
Clinical Utility of Insulin-Like Growth Factor 1 and 2 ... - PLOS
网页2012年9月11日 · Measurement of insulin-like growth factor-1 (IGF-I) has utility for the diagnosis and management of growth disorders, but inter-assay comparison of results has been complicated by a multitude of reference standards, antibodies, detection methods, and pre-analytical preparation strategies.
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