Laminin - Wikipedia
网页Laminins are a family of glycoproteins of the extracellular matrix of all animals. They are major constituents of the basement membrane, namely the basal lamina (the protein network foundation for most cells and organs). Laminins are vital to biological activity, influencing cell differentiation, migration, and adhesion. [1][2]
Laminin - an overview | ScienceDirect Topics
网页Laminin is a family of trimetric proteins containing α, β, and γ subunits with only certain subunits found in mammals and is a key component of basal lamina, a layer of ECM found in many tissues including the brain and blood vessels in the CNS (Nirwane and Yao, 2018).
层粘连蛋白 - 维基百科，自由的百科全书
网页层粘连蛋白 （英語： laminin）是 细胞外基质 的高 分子量 （~400至~900kDa） 糖蛋白。 它们是 基底层 （基底膜 的一层）的主要成分，是大多数细胞和器官的一个蛋白质网络基础。 层粘连蛋白是基底层的重要和生物活性部分，影响细胞分化，迁移和黏附 [1][2]。 层粘连蛋白是由三条不同的 肽链 （α-链，β-链，γ-链）组成异源 三聚体，外形似不对称十字架，呈一条长臂（三链螺旋）和三条短臂（单链），末端均为球状。 其α-链，β-链和γ-链分別有五 …
层粘连蛋白 - 百度百科
网页层粘连蛋白（laminin，LN）存在于各种动物的胚胎及成体组织的各种基膜中，成为其主要成分之一。LN主要存在于基膜的透明层，紧靠细胞基底的表面，通常不存在于正常细胞的顶及侧表面。然而，在恶性细胞则不限于基底表面。
Structural biology of laminins - PubMed
网页2019年9月13日 · Laminins are large cell-adhesive glycoproteins that are required for the formation and function of basement membranes in all animals. Structural studies by electron microscopy in the early 1980s revealed a cross-shaped molecule, which subsequently was shown to consist of three distinct polypeptide c ….
13.5: Laminins - Biology LibreTexts
网页2022年12月30日 · Although there are many other less abundant proteins in the extracellular matrix, laminin is the final ECM molecule to be discussed in this chapter. Laminins are a family of secreted glycoproteins that are found in many ECM formations, and like fibronectin, bind to cells via integrin receptors.
Structural biology of laminins - PMC - National Center for ...
网页2019年9月9日 · Laminins are large cell-adhesive glycoproteins that are required for the formation and function of basement membranes in all animals. Structural studies by electron microscopy in the early 1980s revealed a cross-shaped molecule, which subsequently was shown to consist of three distinct polypeptide chains.
Structure and function of laminin: anatomy of a multidomain ...
网页1990年2月1日 · Laminin is a large (900 kDa) mosaic protein composed of many distinct domains with different structures and functions. Globular and rodlike domains are arranged in an extended four-armed, cruciform shape that is well suited for mediating between distant sites on cells and other components of the extracellular matrix.
The role of laminins in basement membrane function - PMC
网页2016年10月6日 · Laminins are a family of multifunctional macromolecules, ubiquitous in basement membranes, and represent the most abundant structural noncollagenous glycoproteins of these highly specialised extracellular matrices. Their discovery started with the difficult task of isolating molecules produced by cultivated cells or extracted from tissues.
Laminins in Cellular Differentiation - Cell Press
网页2019年11月5日 · The laminin-supported differentiation methods are highly reproducible and can be made chemically defined and fully xeno-free – a prerequisite for preparing therapeutic stem cell-derived cells. In this review we describe recent work on the use of laminin-based cell culture matrices in stem cell differentiation.