Lappaconitine, a C18-diterpenoid alkaloid, exhibits ... - PubMed
网页Lappaconitine is a representative C18-diterpenoid alkaloid extracted from Aconitum sinomontanum Nakai and has been prescribed as a pain relief medicine in China for more than 30 years. This study evaluated its antihypersensitivity activity in the rat models of neuropathic and cancer pains and explor ….
高乌甲素 - 百度百科
网页高乌头中分离出的生物碱，为非麻醉性镇痛药，具有较强的镇痛作用，相当于吗啡镇痛作用，是普通镇痛药氨基比林的7倍，镇痛效果与杜冷丁相当，其维持时间更长，更是曲马多的替代品种。. 另兼有解热、局部麻醉和消肿作用，无依赖性。. 中文名. 高乌甲素 ...
Lappaconitine - an overview | ScienceDirect Topics
网页Lappaconitine is a diterpenoid alkaloid isolated from Aconite and Aconitum carmichaeli, whose hydrobromide salt（Allapinin）was included in the national guidelines for the diagnosis and treatment of ventricular fibrillation in 2012, with a recommendation for its use for rhythm control in patients with atrial fibrillation.
Inhibitory effects of lappaconitine on the neuronal isoforms of …
网页2018年7月10日 · Lappaconitine (LA) has been widely used for postoperative and cancer pain control. LA exhibits excellent analgesic activity with a longer effective time than common local anesthetics such as...
Lappaconitine, a C18-diterpenoid alkaloid, exhibits ... - Springer
网页2018年6月20日 · Lappaconitine is a representative C18-diterpenoid alkaloid extracted from Aconitum sinomontanum Nakai and has been prescribed as a pain relief medicine in China for more than 30 years. This study evaluated its antihypersensitivity activity in the rat models of neuropathic and cancer pains and explored its underlying mechanisms.
Structural Modification and Characteristics of Lappaconitine …
网页2024年8月1日 · Lappaconitine, a diterpene alkaloid isolated from Aconitum sinomontanum Nakai, exhibits a wide range of biological activities, making it a promising candidate for the development of novel derivatives with therapeutic potential. In our research, we executed a two-step transformation via oxidative cleavage of lappaconitine’s vicinal diol using ...
Lappaconitine - an overview | ScienceDirect Topics
网页Lappaconitine is a diterpene alkaloid isolated from Aconitum sinimontanum and widely employed in Chinese and Japanese medicine mainly for analgesic indications. Studies reported that lappaconitine irreversibly inhibited Nav1.7 channels in …
Clinical Effects from Ingestion of Lappaconitine, an Aconitum …
网页2022年5月13日 · Lappaconitine, also called allapinine, is an aconitum alkaloid present in Aconitum sinomontanum (sacred tower giant Chinese monkshood) and has sodium channel effects opposite from aconitine, acting as a sodium channel blocker [2, 12, 13].
Clinical Effects from Ingestion of Lappaconitine, an ... - Springer
网页2022年5月13日 · Lappaconitine, also called allapinine, is an aconitum alkaloid present in Aconitum sinomontanum (sacred tower giant Chinese monkshood) and has sodium channel effects opposite from aconitine, acting as a sodium channel blocker [2, 12, 13].
Synthesis, in vitro and in vivo biological evaluation of novel ...
网页Lappaconitine (LA), a natural compound with a novel C18-diterpenoid alkaloid skeleton, displayed extensive biological profile. Recent research on LA is focused mainly on its anti-tumor and analgesic effects, and therefore we aimed …
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