Metalloproteinase - Wikipedia
网页A metalloproteinase, or metalloprotease, is any protease enzyme whose catalytic mechanism involves a metal. An example is ADAM12 which plays a significant role in the fusion of muscle cells during embryo development, in a process known as myogenesis. Most metalloproteases require zinc, but some use cobalt.
Structure and Function of Human Matrix Metalloproteinases
网页2020年4月26日 · The extracellular matrix (ECM) is a macromolecules network, in which the most abundant molecule is collagen. This protein in triple helical conformation is highly resistant to proteinases degradation, the only enzymes capable of degrading the collagen are matrix metalloproteinases (MMPs). This resistance and maintenance of collagen, and ...
Metalloproteinases and their natural inhibitors in inflammation …
网页2013年8月23日 · Metalloproteinases regulate aspects of immune cell development, effector function, migration and ligand–receptor interactions. They carry out ectodomain shedding of...
Matrix metalloproteinase - Wikipedia
网页Matrix metalloproteinases (MMPs), also known as matrix metallopeptidases or matrixins, are metalloproteinases that are calcium -dependent zinc -containing endopeptidases; [1] other family members are adamalysins, serralysins, and astacins. The MMPs belong to a larger family of proteases known as the metzincin superfamily. [2]
The Roles of Matrix Metalloproteinases and Their Inhibitors in …
网页2020年12月20日 · Matrix metalloproteinases (MMPs) are a family of zinc-dependent extracellular matrix (ECM) remodeling endopeptidases that have the capacity to degrade almost every component of the ECM. The degradation of the ECM is of great importance, since it is related to embryonic development and angiogenesis.
Metalloproteinases and Their Inhibitors: Potential for the …
网页2020年5月25日 · The metalloproteinases (which we refer to MMPs, ADAMs, and ADAMTSs) play a critical role in remodeling of the ECM by proteolytic degradation of ECM components, activation of cell surface proteins, and shedding of membrane-bound receptor molecules.
Metalloproteinase - an overview | ScienceDirect Topics
网页The metalloproteinases are secreted proteins belonging to a family of zinc metalloendopeptidases that have the capacity to cleave extracellular matrix (ECM). Because metalloproteinases can degrade ECM molecules, their main function has been presumed to be remodeling of the ECM.
Matrix Metalloproteinases: From Molecular Mechanisms to …
网页As their name suggests, matrix metalloproteinases are proteases capable of remodeling the extracellular matrix. More recently, MMPs have been demonstrated to play numerous additional biologic roles in cell signaling, immune regulation, and transcriptional control, all of which are unrelated to the degradation of the extracellular matrix.
Metalloproteinases and Their Inhibitors: Potential for the
网页2020年5月25日 · We provide an overview of the structure, function, and the multifaceted role of MMPs, ADAMs, and TIMPs in several diseases via their cellular functions such as proteolysis of other cell signaling factors, degradation and remodeling of the ECM, and other essential protease-independent interactions in the ECM.
Matrix Metalloproteinases - Journal of Biological Chemistry
网页The matrix metalloproteinases (MMPs), also called matrixins, are thought to play a central role in these processes. The expression of most matrixins is transcriptionally regulated by growth factors, hormones, cytokines, and cellular transformation (1, 2).
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