Microprotein - Wikipedia
网页A microprotein (miP) is a small protein encoded from a small open reading frame (smORF). [1] They are a class of protein with a single protein domain that are related to multidomain proteins. [2] Microproteins regulate larger multidomain proteins at …
Microproteins: Overlooked regulators of physiology and disease
网页2023年6月16日 · In this review, we discuss the optimized tools available for microprotein discovery and validation, summarize the biological functions of numerous microproteins, outline the promise for developing microproteins as therapeutic targets, and look forward to the future of the field of microprotein biology.
Microproteins: from behind the scenes to the spotlight
网页2021年5月16日 · Here, we summarize the recent progress in this field mainly from four aspects: (1) brief history and various definitions of microproteins; (2) three main strategies to identify microproteins; (3) multiple regulatory mechanisms of microproteins; (4) biological functions of microproteins, with a particular focus on genome stability maintenance and...
MicroProteins: Dynamic and accurate regulation of protein activity
网页Here, we review characterized microProteins, including their biological roles, regulatory targets, and modes of action. In particular, we focus on microProtein-directed allosteric modulation of key components in light signaling pathways, and we summarize the biogenesis and evolutionary trajectory of known microProteins in plants.
MicroProteins: Expanding functions and novel modes of regulation
网页2021年5月3日 · MicroProteins are small, 5–15-kDa single-domain proteins that are evolutionarily related to multi-domain proteins with sequence homology (Eguen et al., 2015). The single domain of microProteins is often a protein–protein interaction (PPI) domain, through which they can interact with their multi-domain protein targets (Figure 1).
Small, but mighty? Searching for human microproteins and their ...
网页Microprotein is a term that refers to peptides and small proteins that are translated from smORFs and can include known genes. Microprotein discovery and characterization reshapes our understanding of proteome composition and reveals new biological pathways [1].
The functions of short ORFs and their microproteins
网页2020年3月24日 · The abundance and roles of microproteins, which are defined as having fewer than 100 amino acids (aa), remain largely unknown. To systematically annotate short CDSs and assess their translation,...
Microproteins—Discovery, structure, and function
网页2023年8月21日 · In this review, we provide a brief overview of microprotein discovery methods, then examine examples of microprotein structures (and, conversely, intrinsic disorder) that have been experimentally determined using crystallography, cryo-electron microscopy, and NMR, which provide insight into their molecular functions and mechanisms.
Small but mighty: the rise of microprotein biology in neuroscience
网页The microprotein MAVI1, encoded by the gene Smim30, is a transmembrane protein localized to the endoplasmic reticulum where it interacts with the mitochondrial protein MAVS to block innate immune responses (Shi et al., 2023). The expression of MAVI1 in the human brain suggests potential additional functions of MAVI1 beyond antiviral innate ...
Microproteins-Discovery, structure, and function - PubMed
网页In this review, we provide a brief overview of microprotein discovery methods, then examine examples of microprotein structures (and, conversely, intrinsic disorder) that have been experimentally determined using crystallography, cryo-electron microscopy, and NMR, which provide insight into their molecular functions and mechanisms.
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