NR4A3: A Key Nuclear Receptor in Vascular Biology, …
网页2021年10月21日 — This paper reviews the major findings involving NR4A3 (Neuron-derived Orphan Receptor 1, NOR-1) in the cardiovascular remodeling operating in these diseases. Keywords: NOR-1; abdominal aortic aneurysm; atherosclerosis; cardiovascular remodeling.
Nuclear receptor 4A3 - Wikipedia
网页The nuclear receptor 4A3 (NR4A3) (nuclear receptor subfamily 4, group A, member 3) also known as neuron-derived orphan receptor 1 (NOR1) is a protein that in humans is encoded by the NR4A3 gene. [5] NR4A3 is a member of the nuclear receptor family of intracellular transcription factors .
NR4A3 Gene - GeneCards | NR4A3 Protein | NR4A3 Antibody
网页2024年8月6日 — NR4A3 (Nuclear Receptor Subfamily 4 Group A Member 3) is a Protein Coding gene. Diseases associated with NR4A3 include Chondrosarcoma, Extraskeletal Myxoid and Chondrosarcoma. Among its related pathways are Gene expression (Transcription) and Nuclear receptors.
Circ Res 上海交通大学医学院附属瑞金医院张瑞岩/闫小响团队揭示血管平滑肌细胞NR4A3 …
网页本研究首次揭示血管平滑肌细胞NR4A3在动脉中层钙化中的重要作用，发现NR4A3介导的糖酵解增强和乳酸增多促进Phospho1启动子区域组蛋白H3K18位点的乳酰化修饰，最终促进了动脉钙化的发生。. 动脉中层钙化 (Medial arterial calcification, MAC)是指在动脉中层出现钙磷 …
NR4A nuclear receptors restrain B cell responses to antigen
网页2020年8月31日 — Here, we show that Nr4a1 and Nr4a3 play partially redundant roles to restrain B cell responses to antigen in the absence of co-stimulation and do so, in part, by repressing the expression of BATF...
Orphan receptor NR4A3 is a novel target of p53 that ... - Nature
网页2018年11月19日 — Collectively, our studies revealed a novel transcriptional target of p53, NR4A3, which triggers apoptosis and thus likely has a tumor suppressive role in breast and lung cancers.
The nuclear receptor 4A family members: mediators in human …
网页2020年11月3日 — The Nuclear receptor 4A (NR4A) subfamily, which belongs to the nuclear receptor (NR) superfamily, has three members: NR4A1 (Nur77), NR4A2 (Nurr1) and NR4A3 (Nor1). They are gene regulators with broad involvement in various signaling pathways and human disease responses, including autophagy.
NR4A3 nuclear receptor subfamily 4 group A member 3 [ (human)]
网页Low expression of NR4A gene family members (NR4A1, NR4A3) and 1-alpha25-dihydroxyvitamin D3 receptor (VDR) genes is demonstrated in peripheral blood mononuclear cells of multiple sclerosis patients. The pathognomic rearrangement of NR4A3 is a useful diagnostic feature in identifying cellular extraskeletal myxoid chondrosarcomas.
Nuclear Receptor 4A (NR4A) Family – Orphans No More
网页The nuclear receptor NR4A3 (Nor1, TEX, MINOR, CHN) is the third member of the NR4A family and shares many of the same characteristics reported for NR4A1 and NR4A2. NR4A3-mediated transactivation and interactions with various cis-elements, except that unlike NR4A1 and NR4A2, NR4A3 does not form a heterodimer with RXR [15, 16].
Potential Roles of Nr4a3-Mediated Inflammation in ... - Springer
网页2024年1月23日 — At present, research on the role of Nr4a3 in the pathophysiology of inflammation is considerably limited, especially with respect to its role in the central nervous system (CNS). In this review, we discuss the role of Nr4a3 in multiple sclerosis, Alzheimer’s disease, retinopathy, Parkinson’s disease, and other CNS diseases.