Polyene - Wikipedia
网页In organic chemistry, polyenes are poly- unsaturated, organic compounds that contain at least three alternating double (C=C) and single (C−C) carbon–carbon bonds. These carbon–carbon double bonds interact in a process known as conjugation, resulting in some unusual optical properties.
Amphotericin B and Other Polyenes—Discovery, Clinical Use, …
网页2020年11月27日 · Polyenes such as amphotericin B have a controversial image. They are the antifungal drug class with the broadest spectrum, resistance development is still relatively rare and fungicidal properties are extensive. Yet, they come with a significant host toxicity that limits their use.
13.15: Polyenes - Chemistry LibreTexts
网页Polyunsaturated alkenes, or polyenes, are compounds that have several carbon-carbon double bonds. The double bonds can be spaced out along the carbon chain, with several carbon-carbon single bonds separating them. In this case they are called isolated polyenes.
Polyene - an overview | ScienceDirect Topics
网页Polyenes are a class of broad spectrum antifungal compounds with a cyclic amphiphilic macrolide substructure which are derived from a species of Streptomyces bacteria. 11 The polyenes are antifungal by virtue of binding to ergosterol, which is a prevalent steroid in the fungal cell wall, resulting in depolarization of the membrane leading to inc...
Polyene Antibiotics Physical Chemistry and Their Effect on Lipid ...
网页2022年6月30日 · Polyene antibiotics have been used for more than 60 years to combat protozoa and fungal infections through the induced permeability of the cell membrane. Some have a differentiated action between membranes with cholesterol and ergosterol, with a high degree of effectiveness and generate very low resistance in fungal pathogens [ 339 ].
Polyene - an overview | ScienceDirect Topics
网页2020年12月1日 · Polyenes are usually defined as materials having an even number of methyene groups (=CH–) that are bonded by covalent forces to form a linear chain containing one p electron on each carbon atom.
Polyenes and Polyvinylenes - SpringerLink
网页2018年7月22日 · Polyenes are formally defined as materials containing an even number of methyne (=CH–) groups covalently bonded to form a linear carbon chain bearing one p electron on each carbon atom [3, 4, 5, 6].
The pore-forming action of polyenes: From model membranes to …
网页2019年2月1日 · The primary biological target of the polyenes is the plasma membrane of cells and the unicellular organisms whose integrity can be disturbed in several different ways. By far the best-known and well-studied mechanism is the pore-forming model, i.e., the formation of channels in the membranes [32, 33].
Synthesis of most polyene natural product motifs using just 12 …
网页2014年5月11日 · This analysis generated the intriguing hypothesis that the polyene motifs found in >75% of all polyene natural products can be prepared using just 12 MIDA boronate building blocks and one...
Structural and Mechanistic Insights into Chain Release of the …
网页2021年12月28日 · A review. Polyene macrolides are a large family of natural products typically produced by soil Actinomycetes. Polyene macrolides are usually biosynthesized by modular and large type I polyketide synthases (PKSs), followed by several steps of sequential post-PKS modifications such as region-specific oxidns. and glycosylations.