SMAD4 gene - MedlinePlus
网页The SMAD4 gene provides instructions for making a protein involved in transmitting chemical signals from the cell surface to the nucleus. Learn about this gene and related health conditions.
SMAD (protein) - Wikipedia
网页Smad4 is the only known human Co-Smad, and has the role of partnering with R-Smads to recruit co-regulators to the complex. [ 5 ] Finally, Smad6 and Smad7 are I-Smads that work to suppress the activity of R-Smads.
Mothers against decapentaplegic homolog 4 - Wikipedia
网页SMAD4, also called SMAD family member 4, Mothers against decapentaplegic homolog 4, or DPC4 (Deleted in Pancreatic Cancer-4) is a highly conserved protein present in all metazoans. It belongs to the SMAD family of transcription factor proteins, which act as mediators of TGF-β signal transduction.
SMAD4 Gene - GeneCards | SMAD4 Protein | SMAD4 Antibody
网页2024年8月6日 · This gene encodes a member of the Smad family of signal transduction proteins. Smad proteins are phosphorylated and activated by transmembrane serine-threonine receptor kinases in response to transforming growth factor (TGF)-beta signaling.
The role of TGF-β/SMAD4 signaling in cancer - PMC
网页2018年1月12日 · The canonical TGF-β/SMAD4 signaling pathway plays a tumor suppressive role at early stages, mainly by inducing cell cycle arrest and apoptosis. SMAD4 functions at the G1/S checkpoint to make cells stay at the G1 phase, thus leading to cell cycle arrest 17.
About Mutations in the SMAD4 Gene | Memorial Sloan …
网页2023年7月17日 · If you have a mutation in the SMAD4 gene, this means you have a condition called Juvenile Polyposis syndrome (JPS). JPS increases your risk of developing polyps (growths of tissue) in your colon or rectum. These polyps can lead to an increased risk for colorectal (colon and rectal) cancer.
Consequences of Mutations and Abnormal Expression of SMAD4 …
网页2021年4月13日 · Loss of SMAD4 functions due to mutations or abnormal expression can suppress the inhibition of tumor growth and support the tumor progression. Functions of SMAD4 and its variants in T cells are being studied extensively, to better understand the SMAD4 functions in T cells.
跳至内容