Neuraminidase - Wikipedia
网页Exo-α-sialidase (EC 3.2.1.18, sialidase, neuraminidase; systematic name acetylneuraminyl hydrolase) is a glycoside hydrolase that cleaves the glycosidic linkages of neuraminic acids:
Targeted glycan degradation potentiates the anticancer immune ... - Nature
网页2020年8月17日 — Since these glycans are not canonically druggable, we designed an αHER2 antibody–sialidase conjugate that potently and selectively strips diverse sialoglycans from breast cancer cells.
α2-3,6,8,9 Neuraminidase A | NEB
网页α2-3,6,8,9 Neuraminidase A is a broad specificity sialidase, which cleaves linear and branched non-reducing terminal sialic acid residues from glycoproteins, glycopeptides, and oligosaccharides. It can be used for glycan analysis and characterization and intact glycoprotein remodeling, in vitro and in vivo .
神经氨酸酶 - 维基百科，自由的百科全书
网页神经氨酸酶 （Neuraminidase）又称 唾液酸酶 （sialidase），是分布于 流感病毒 被膜上的一种 醣蛋白，它具有 抗原性，可以催化唾液酸 水解，协助成熟流感病毒脱离宿主细胞感染新的细胞，在流感病毒的生活周期中扮演了重要的角色。. 在甲型流感病毒中，神经 ...
Sialidase - an overview | ScienceDirect Topics
网页Sialidases are glycosidases responsible for the removal of α-glycosidically linked sialic acid residues from carbohydrate portions of glycoproteins and glycolipids, this process being the initial step in the degradation of such glycoconjugates.
Targeted desialylation and cytolysis of tumour cells by fusing a ...
网页2024年5月1日 — Here we show that a BiTE–sialidase fusion protein enhances the susceptibility of solid tumours to BiTE-mediated cytolysis of tumour cells via targeted desialylation—that is, the removal of...
Structure of the immunoregulatory sialidase NEU1 | Science …
网页2023年5月19日 — Neuraminidase-1 (sialidase-1 or NEU1) is a ubiquitously expressed mammalian sialidase located in lysosomes and on the cell membrane. Because of its modulation of multiple signaling processes, it is a potential therapeutic target for cancers and immune disorders.
The Function of Sialidase Revealed by Sialidase Activity Imaging …
网页2021年3月20日 — Sialidase cleaves sialic acid residues from glycans such as glycoproteins and glycolipids. In the brain, desorption of the sialic acid by sialidase is essential for synaptic plasticity, learning and memory and synaptic transmission. BTP3-Neu5Ac has been developed for sensitive imaging of sialidase enzyme activity in mammalian tissues.
Sialidase Inhibitors with Different Mechanisms - PMC
网页2022年10月10日 — Sialidases, or neuraminidases, are enzymes that catalyze the hydrolysis of sialic acid (Sia)-containing molecules, mostly removal of the terminal Sia (desialylation). By desialylation, sialidase can modulate the functionality of the target compound and is thus often involved in biological pathways.
Sialidase and Sialyltransferase Inhibitors: Targeting Pathogenicity …
网页2021年7月29日 — Sialidases (SAs) and sialyltransferases (STs), the enzymes responsible for removing and adding sialic acid to other glycans, play essential roles in viruses, bacteria, parasites, and humans. Sialic acid is often the terminal sugar on glycans protruding from the cell surface in humans and is an important component for recognition and cell function.
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