USP24 Gene - GeneCards | UBP24 Protein | UBP24 Antibody
网页2024年8月6日 · USP24 (Ubiquitin Specific Peptidase 24) is a Protein Coding gene. Diseases associated with USP24 include Kaufman Oculocerebrofacial Syndrome and Hennekam Syndrome. Among its related pathways are Deubiquitination and Metabolism of proteins. Gene Ontology (GO) annotations related to this gene include binding and cysteine-type peptidase activity.
USP24 ubiquitin specific peptidase 24 [ (human)] - National …
网页2024年9月8日 · USP24 Is a Cancer-Associated Ubiquitin Hydrolase, Novel Tumor Suppressor, and Chromosome Instability Gene Deleted in Neuroblastoma. USP24 stabilizes bromodomain containing proteins to promote lung cancer malignancy.
USP24 promotes drug resistance during cancer therapy
网页2021年4月12日 · Our evidences show that only USP24 regulates ABC transporters and DDR activity simultaneously, and we also found a novel USP24 inhibitor, NCI677397, that can inhibit drug resistance by...
USP24 induces IL-6 in tumor-associated microenvironment by ... - Nature
网页2018年9月28日 · USP24 stabilizes p300 and β-TrCP to increase the levels of histone-3 acetylation and NF-κB, and decreases the levels of DNMT1 and IκB, thereby increasing IL-6 transcription in M2 macrophages ...
USP24-i-101 targeting of USP24 activates autophagy to inhibit …
网页2024年3月15日 · USP24 functional knockout, USP24 C1695A, or targeting USP24 by USP24-i-101 inhibited drug resistance and activated autophagy in gefitinib-induced drug-resistant mice with doxycycline-induced EGFR...
USP24 promotes drug resistance during cancer therapy
网页2021年4月12日 · USP24 increases the TMB and induces the pumping of drugs out of cells to induce drug resistance. A novel, USP24-specific inhibitor, NCI677397, could stabilize the genome, reduce cancer stemness characteristics, and increase the concentration of a drug inside cells to block the emergence of drug resistance (Fig. 8B).
Ubiquitin‐specific peptidase 24 accelerates aerobic glycolysis and ...
网页2023年6月2日 · Ubiquitin-specific peptidase 24 (USP24), a member of the deubiquitinase family, plays an important role in tumor regulation. However, the role of USP24 in gastric cancer (GC) is unknown. The aim of our study was to explore the role of USP24 in GC to seek new therapeutic targets for GC.
Related cellular signaling and consequent ... - ScienceDirect
网页2024年4月1日 · Ubiquitin-specific protease 24 (USP24) is an essential member of the deubiquitinating protease family found in eukaryotes. It engages in interactions with multiple proteins, including p53, MCL-1, E2F4, and FTH1, among others.
USP24 Is a Cancer-Associated Ubiquitin Hydrolase, Novel Tumor ... - PubMed
网页2021年3月1日 · Deubiquitinating enzymes are increasingly recognized to play important roles in cancer, with many acting as oncogenes or tumor suppressors. In this study, we employed a bioinformatics approach to screen for enzymes from this family involved in cancer and found USP24 as a potent predictor of poor outcomes in …
USP24 - Wikipedia
网页Ubiquitin carboxyl-terminal hydrolase 24 is an enzyme that in humans is encoded by the USP24 gene. [5] [6]