Axotomy - Wikipedia
网页In cellular neuroscience, an axotomy (from axo- 'axon' and -tomy 'surgery') is the cutting or otherwise severing of an axon. This type of denervation is often used in experimental studies on neuronal physiology and neuronal death or survival as a method to better understand nervous system diseases .
Axotomy - an overview | ScienceDirect Topics
网页The term “axotomy” refers to an interruption of axonal continuity due to during injury or disease and thereby divided into two cytoplasmic compartments. The part of the axon remaining in continuity with the cell body is referred to as the proximal nerve stump, while the axonal region isolated from the neuronal soma is the distal segment.
axotomy - 百度百科
网页axotomy，英语单词，主要用作名词，作名词时译为“轴索显微外科术”。
Distal axotomy enhances retrograde presynaptic excitability …
网页2017年9月20日 · Using microfluidic chambers to separate and injure distal axons, we show that axotomy causes retrograde dendritic spine loss at directly injured pyramidal neurons followed by retrograde ...
Unraveling Axon Guidance during Axotomy and Regeneration
网页2021年8月3日 · In this review, we present findings on growth cone guidance and canonical guidance cues mechanisms, followed by a description and comparison of growth cone pathfinding mechanisms after axotomy, in regenerative and …
Programmed axon degeneration: from mouse to mechanism to medicine - Nature
网页2020年3月9日 · Wallerian degeneration was originally defined as the degeneration of an axon that takes place distal to an injury, characterized by granular disintegration of the cytoskeleton, mitochondrial...
Frontiers | Synaptic Plasticity on Motoneurons After Axotomy: A ...
网页2020年4月30日 · Different phases of synaptic and glia plasticity around cell bodies of axotomized motoneurons. Axotomy induces chromatolysis and rapid changes in gene expression due to positive injury signals arriving at the cell body and negative signals due to lost trophic support from muscle.
In-vivo single neuron axotomy triggers axon regeneration to …
网页2013年6月25日 · To what extent, how and when axons respond to injury in the highly interconnected grey matter is poorly understood. Here we use two-photon imaging and focused ion beam–scanning electron ...
Axotomy as an experimental model of neuronal injury and cell …
网页Axonal transection provides very useful paradigms to study cellular responses to injury, mechanisms of regeneration and plasticity, and processes that lead to nerve cell degeneration. Moreover, models of axotomy are valuable for testing experimental therapeutic approaches.
Traumatic Axonal Injury: Mechanisms and Translational …
网页2016年2月11日 · Traumatic axonal injury (TAI) is an important pathoanatomical subgroup of traumatic brain injury (TBI) and a major driver of mortality and functional impairment. Experimental models have provided insights into the effects of mechanical deformation on the neuronal cytoskeleton and the subsequent processes that drive axonal injury.
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