KIT (gene) - Wikipedia
网页Proto-oncogene c-KIT is the gene encoding the receptor tyrosine kinase protein known as tyrosine-protein kinase KIT, CD117 (cluster of differentiation 117) or mast/stem cell growth factor receptor (SCFR). [5] Multiple transcript variants encoding different isoforms have been found for this gene.
KIT (CD117): a review on expression in normal and neoplastic …
网页CD117 (KIT) is a type III receptor tyrosine kinase operating in cell signal transduction in several cell types. Normally KIT is activated (phosphorylated) by binding of its ligand, the stem cell factor. This leads to a phosphorylation cascade ultimately activating various transcription factors in different cell types.
Pathology Outlines - CD117
网页2 天之前 · CD117 is a proto-oncogene activated in GIST tumors, receptor for kit protein, a 145 kD tyrosine kinase growth factor receptor protein
CD117 - an overview | ScienceDirect Topics
网页CD117, also known as c-kit, is a tyrosine kinase receptor that is expressed in most hemopoietic stem and progenitor cells, as well as mast cells. It is a marker used for the detection of mast cell disorders and identification of myeloblasts in acute leukemias.
Selective hematopoietic stem cell ablation using CD117 ... - Nature
网页2019年2月6日 · CD117-ADC potently depletes endogenous HSCs. We created a single-agent antibody-drug-conjugate targeting the antigen CD117 (c-kit), which is a critical hematopoietic stem and progenitor...
CD117 - an overview | ScienceDirect Topics
网页The KIT protein or CD117 is a transmembrane protein for a tyrosine kinase receptor encoded by the proto-oncogene c-kit, which, when bound to its ligand stem cell factor (SCF), is essential to the development, proliferation, and maturation of several cell types, including germ cells.
Diagnostic utility of C-kit protein (CD117) expression in ...
网页2019年11月7日 · CD117 (c-kit proto-oncogene) is a Type-III transmembrane receptor tyrosine Kinase that is encoded by the c-kit gene which is placed on the human chromosome segment 4q11.1,2 C-kit leads to activation of specific intracellular signal transduction cascades and thus plays a key part in normal differentiation and growth of different cell types.3-5
CD117/c-kit in Cancer Stem Cell-Mediated Progression and …
网页2018年3月8日 · CD117 develops an overactivation or ligand-independent constitutive mutation to become oncogenic. Overactivation of CD117 causes alterations in the signaling pathways upregulating proliferation, cell survival, migration, and differentiation.
Anti-human CD117 CAR T-cells efficiently eliminate healthy and ...
网页2020年5月1日 · Anti-CD117 CAR T-cells were highly active against all resulting CD117 + cell lines, although elimination was faster and more complete in CD117-medium and CD117-high than in CD117-mixed...
Prognostic value of CD117 in cancer: a meta-analysis - PMC
网页2014年2月15日 · Background: The prognostic value of CD117 expression in cancers has been evaluated for several years while the results remain controversial. We thus performed a systematic review and meta-analysis of studies assessing the impact of CD117 expression on overall survival (OS) and disease-free survival (DFS) to clarify this issue.
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