网页study was to assess for the first time the ciliotoxicity and cytotoxicity of nasal sprays intended for chronic treatment (with repeated doses) using a previously designed set -up for CBF measurements.
网页In the present study, we examined the ciliotoxicity and cytotoxicity of repeated doses of the nasal spray formulation. We have previously shown that the combination of the stan-dardised ready-to-use 3D nasal MucilAir™ in vitro model and high-speed phase-contrast microscopy is simple and efficient for single-dose ciliotoxicity studies.
Ciliotoxicity of intranasal formulations: Menthol enantiomers - Su ...
网页Abstract. It is shown, using in vitro measurements of beat frequency of rat tracheal cilia, that (+)- (1S, 2R, 5S)-menthol and (−)− (1R, 2S, 5R)−menthol have equipotent ciliotoxicities despite the fact that inhalation of menthol vapours from the crystals of the pure enantiomers show clearly that the (−)− (1R, 2S, 5R)-menthol produces ...
Ciliary beat frequency of - ScienceDirect
网页2020年8月1日 · A key parameter to determine mucociliary clearance is ciliary beat frequency (CBF). The objective of this study was to validate the high-speed digital imaging for CBF measurements in nasal MucilAir™ in vitro model and to test its potential for ciliotoxicity studies to evaluate the safety of investigational nasal drug formulations. Our CBF ...
A Systematic Safety Evaluation of Nanoporous Mannitol Material …
网页2020年5月1日 · Measurement of Ciliotoxicity. At the stage of detachment of APIs from carrier surface, carriers would be trapped at the narrow tracheas, and then cleared by cilia. Hence, a low ciliotoxicity of carriers was essential for DPIs.
The Influence of Drugs on Nasal Ciliary Movement
网页Cholinergic drugs and β-adrenergic drugs exert a ciliostimulatory effect. It is the purpose of this review to summarize the present knowledge of ciliotoxicity of drugs and additives and to give recommendations for the use of ciliofriendly drugs in nasal preparations.
Lowering of sodium deoxycholate-induced nasal ciliotoxicity with ...
网页Aim: To lower the nasal ciliotoxicity of sodium deoxycholate (SDC) in combination with cyclodextrins (CD). Methods: The erythrocyte hemolysis test was carried out to evaluate the damaging effect of SDC on the erythrocyte membrane. The in situ toad palate model and scanning electron microscope technique were used to investigate the nasal ...
Preliminary studies for the development of intranasal …
网页2016年3月23日 · Nasal ciliotoxicity caused by elevated proportions of surfactants and co-surfactants is also of great concern as it is directly correlated with patient compliance. Phase diagrams are used for the selection of suitable surfactant, co-surfactant and their combinations that provide maximum nanoemulsion region.
Betadine has a ciliotoxic effect on ciliated human respiratory cells
网页Ciliary beat frequency was analysed using a high-speed camera on a computer imaging system. Results: Undiluted 10 per cent Betadine (n = 6) decreased the proportion of actively beating cilia over 1 minute (p < 0.01). Ciliary beat frequency decreased from 11.15 ± 4.64 Hz to no detectable activity.
In Vitro Ciliotoxicity and Cytotoxicity Testing of Repeated …
网页2021年10月20日 · This study demonstrates a dose-dependent and time-dependent effect of the nasal sprays on ciliary activity and cytotoxicity using CBF measurements and ultrastructural analysis, respectively and suggests that such in vitro assays have great potential for topical nasal drug screening. Expand. [PDF] Semantic Reader. Save to Library. Create Alert. Cite