Coenzyme A - Wikipedia
网页Coenzyme A (CoA, SHCoA, CoASH) is a coenzyme, notable for its role in the synthesis and oxidation of fatty acids, and the oxidation of pyruvate in the citric acid cycle. All genomes sequenced to date encode enzymes that use coenzyme A as a substrate, and around 4% of cellular enzymes use it (or a thioester) as a substrate.
Coenzyme A - an overview | ScienceDirect Topics
网页Coenzyme A is an ubiquitous cofactor involved in cellular oxidative pathways including fatty acid β-oxidation, carbohydrate and amino acid oxidations, and Krebs cycle; and in lipid synthesis, protein modifications and membrane trafficking [78,79].
Coenzyme a Biochemistry: From Neurodevelopment to …
网页2021年8月2日 · Coenzyme A (CoA) is an essential cofactor in all living organisms. It is involved in a large number of biochemical processes functioning either as an activator of molecules with carbonyl groups or as a carrier of acyl moieties.
辅酶A - 百度百科
网页辅酶A（coenzyme A），是一种辅酶，值得注意的是其在合成和氧化脂肪酸的角色，和在三羧酸循环中氧化丙酮酸。 所有基因组测序日期编码的酶，即利用辅酶A作为底物，并在4%左右的细胞酶中使用（或硫酯，例如乙酰-CoA）作为基材。
Coenzyme A biosynthesis: mechanisms of regulation, function
网页2024年6月13日 · The pivotal metabolic cofactor coenzyme A (CoA) functions at the nexus of catabolism, anabolism and metabolic signalling. As a specialized low-molecular-weight thiol, it serves as the...
辅酶A - 维基百科，自由的百科全书
网页辅酶A （英語： coenzyme A，簡稱 CoA 、 CoASH 或 HSCoA）是一種 輔酶，值得注意的是其在合成和氧化 脂肪酸 的角色，和在 三羧酸循環 中氧化 丙酮酸。 利用輔酶A作為 底物，並在4％左右的細胞酶中（或 硫酯，例如 乙酰-CoA）作為基材。 在人類中，輔酶A生物合成需要 半胱氨酸 、 泛酸 和 三磷酸腺苷 （ATP）。 主要參與脂肪酸以及丙酮酸的代謝。 辅酶A是泛酸在生物体内主要活性形式，由3',5'-ADP以磷酸酐键连接4-磷酸泛酰-β-巯基乙胺形成 …
Coenzyme A: to make it or uptake it? - Nature
网页2016年8月24日 · The central role of coenzyme A (CoA) (see Supplementary information S1 (figure)) in energy and fatty acid metabolism has been firmly established since its discovery more than 70 years ago as the...
Coenzyme | Enzymes, Metabolism & Function | Britannica
网页Coenzyme, Any of a number of freely diffusing organic compounds that function as cofactors with enzymes in promoting a variety of metabolic reactions. Coenzymes participate in enzyme-mediated catalysis in stoichiometric (mole-for-mole) amounts, are modified during the reaction, and may require.
The Pathophysiological Role of CoA - PMC - National Center for ...
网页2020年11月28日 · Coenzyme A (CoA or CoA-SH) is an essential cofactor of cellular metabolism in all living organisms. Pantothenic acid (Pan, commonly known as vitamin B5) is the only nutritionally essential component involved in the synthesis of CoA, which is required for many biochemical processes (see below) …
Regulation of coenzyme A levels by degradation: the ‘Ins and Outs’
网页Coenzyme A (CoA) is the predominant acyl carrier in mammalian cells and a cofactor that plays a key role in energy and lipid metabolism. CoA and its thioesters (acyl-CoAs) regulate a multitude of metabolic processes at different levels: as substrates, allosteric modulators, and via post-translational modification of histones and other non ...