Cytolethal distending toxin - Wikipedia
网页Cytolethal distending toxins (CDTs) are bacterial toxins that damage DNA and cause cell cycle arrest and death. Learn about their structure, sources, history, and effects on different cell types.
From DNA Damage to Cancer Progression: Potential Effects of …
网页2021年11月15日 · Cytolethal distending toxin (CDT), one of the most important genotoxins, is produced by several gram-negative bacteria and is involved in bacterial pathogenesis. Recent studies have shown that bacteria producing this peculiar genotoxin target host DNA, which potentially contributes to development of …
The Cytolethal Distending Toxin Effects on Mammalian Cells: A …
网页2014年6月11日 · The cytolethal distending toxin (CDT) is produced by many pathogenic Gram-negative bacteria and is considered as a virulence factor. In human cells, CDT exposure leads to a unique cytotoxicity associated with a characteristic cell distension and induces a cell cycle arrest dependent on the DNA damage response (DDR) triggered by …
Revisiting bacterial cytolethal distending toxin structure and …
网页2023年11月14日 · Cytolethal distending toxins (CDTs) are intracellular-acting bacterial genotoxins generated by a diverse group of mucocutaneous human pathogens. CDTs must successfully bind to the plasma membrane of host cells …
Cytolethal distending toxin: from genotoxin to a potential …
网页2021年8月11日 · Cytolethal Distending Toxin (CDT) belongs to the AB toxin family and is produced by a plethora of Gram-negative bacteria. Eight human-affecting enteropathogens harbor CDT that causes irritable bowel syndrome (IBS), dysentery, chancroid, and periodontitis worldwide.
Cytolethal Distending Toxin Subunit B: A Review of …
网页2019年10月12日 · The Cytolethal Distending Toxin (CDT) is a bacterial virulence factor produced by several Gram-negative pathogenic bacteria. These bacteria, found in distinct niches, cause diverse infectious diseases and produce CDTs differing in …
Cytolethal distending toxins - PubMed
网页The cytolethal distending toxins (CDTs) constitute the most recently discovered family of bacterial protein toxins. CDTs are unique among bacterial toxins as they have the ability to induce DNA double strand breaks (DSBs) in both proliferating and nonproliferating cells, thereby causing irreversible …
The Cytolethal Distending Toxin Contributes to Microbial
网页2016年12月5日 · This review summarizes the current status and recent advances in our understanding of the role that the cytolethal distending toxin (Cdt) plays as a virulence factor in promoting disease by toxin-producing pathogens. A major focus of this review is on the relationship between structure and function …
Cytolethal Distending Toxin - an overview | ScienceDirect Topics
网页Cytolethal distending toxins (CDTs) are a newly discovered family of proteins classified as cyclomodulins which interfere with the cell cycle of the host cells by damaging the DNA (Ceelen et al., 2006).
The Biology of the Cytolethal Distending Toxins - MDPI
网页The cytolethal distending toxins (CDTs), produced by a variety of Gram-negative pathogenic bacteria, are the first bacterial genotoxins described, since they cause DNA …
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