Disulfide - Wikipedia
网页In chemistry, a disulfide (or disulphide in British English) is a compound containing a R−S−S−R′ functional group or the S 2− 2 anion. The linkage is also called an SS-bond or sometimes a disulfide bridge and usually derived from two thiol groups.
Disulfide - an overview | ScienceDirect Topics
网页Disulfides are compounds with the general formula R S S R′. These compounds are more stable than the corresponding peroxides that contain the O O group. When the R and R′ are aliphatic radicals with two to five carbons, these compounds decompose in the range of temperatures from 300°C to 500°C.
Structural Biochemistry/Chemical Bonding/ Disulfide bonds
网页2020年1月26日 · A disulfide bond, also called an S-S bond, or disulfide bridge, is a covalent bond derived from two thiol groups. In biochemistry, the terminology R-S-S-R connectivity is commonly used to describe the overall linkages.
From structure to redox: the diverse functional roles of disulfides …
网页This review provides a comprehensive overview of the functional roles of disulfide bonds and their relevance to human disease. The critical roles of disulfide bonds in protein structure stabilization and redox regulation of protein activity are addressed.
Cysteines and Disulfide Bonds as Structure-Forming Units: Insights …
网页2020年4月23日 · Disulfide bonds are a central structural element which stabilizes the mature proteins' 3D structure and/or exhibit physiologically relevant redox activity (Bosnjak et al., 2014). They are mostly found in secretory proteins and extracellular domains of membrane proteins.
What is a Disulfide Bond (1 of 4) | NEB
网页Disulfide bonds are formed by the oxidation of sulfhydryl groups between two cysteine side chains, resulting in a covalent bond, greatly increasing the stability of the protein. This process occurs during the folding of a protein.
Disulfide Bond - an overview | ScienceDirect Topics
网页A disulfide bond is a post-translational modification that covalently links the sulfur atoms of two cysteine residues in close spatial proximity so that proteins are internally or externally cross-linked.
Formation and transfer of disulphide bonds in living cells
网页2002年11月1日 · Key Points. The formation of structural disulphide bonds in cellular proteins is a catalysed process that involves many proteins and small molecules. The primary pathways of disulphide-bond...
网页Protein disulphide bonds are formed in the endoplasmic reticulum of eukaryotic cells and the periplasmic space of prokaryotic cells. The main pathways that catalyse the formation of protein ...
Disulfide Bonds Play a Critical Role in the Structure and Function …
网页2022年1月1日 · We started with three RBD models, first with all four disulfide bonds intact (“RBD”), second with the single disulfide bond between C480-C488 reduced “RBD (−1 SS)” and third with all S—S bonds reduced “RBD (−4 SS)”. Two simulations of 2 µs were performed for each model.
跳至内容