Excitotoxicity - Wikipedia
网页Excitotoxicity can occur from substances produced within the body (endogenous excitotoxins). Glutamate is a prime example of an excitotoxin in the brain, and it is also the major excitatory neurotransmitter in the central nervous system of mammals. [14]
Excitotoxicity - an overview | ScienceDirect Topics
网页Excitotoxicity is a hyperacute secondary injury mechanism that initiates shortly after a brain insult. It is characterized by pathologically high levels of excitatory neurotransmitters such as glutamate that allows excessive influx of calcium and sodium ions into the cell.
Excitotoxicity: Still Hammering the Ischemic Brain in 2020
网页2020年10月26日 · Interest in excitotoxicity expanded following its implication in the pathogenesis of ischemic brain injury in the 1980s, but waned subsequent to the failure of N-methyl-D-aspartate (NMDA) antagonists in high profile clinical stroke trials. Nonetheless there has been steady progress in elucidating underlying mechanisms.
Going the Extra (Synaptic) Mile: Excitotoxicity as the Road Toward ...
网页2020年4月24日 · Excitotoxicity is a phenomenon that describes the toxic actions of excitatory neurotransmitters, primarily glutamate, where the exacerbated or prolonged activation of glutamate receptors starts a cascade of neurotoxicity that ultimately leads to the loss of neuronal function and cell death.
Molecular mechanisms of excitotoxicity and their relevance to ...
网页2009年4月3日 · This review discusses the current understanding of excitotoxic mechanisms and how they are involved in the pathogenesis of neurodegenerative diseases.
Excitotoxicity - ScienceDirect
网页2019年1月1日 · Excitotoxicity is a complex process triggered by glutamate receptor activation that results in the degeneration of dendrites and cell death. All subcellular compartments are affected by the excitotoxic process, with changes in the cytosol, mitochondria, endoplasmic reticulum (ER), and nucleus being pivotal.
Excitotoxic injury in Hypoxia-Ischemia - Basic Neurochemistry
网页Excitotoxicity (toxic glutamate receptor activation) is a key mediator of central neuronal loss consequent to hypoxic-ischemic insults [8].
Molecular and cellular mechanisms of excitotoxic neuronal death
网页Glutamate receptor-mediated excitatory neurotransmission plays a key role in neural development, differentiation and synaptic plasticity. However, excessive stimulation of glutamate receptors induces neurotoxicity, a process that has been defined as excitotoxicity. Excitotoxicity is considered to be a major mechanism of cell death in a number ...
Excitotoxic inactivation of constitutive oxidative stress ...
网页2017年12月22日 · Excitotoxicity, a critical process in neurodegeneration, induces oxidative stress and neuronal death through mechanisms largely unknown. Since oxidative stress activates protein kinase D1 (PKD1) in...
Mechanisms of Excitotoxicity and Excitoprotection
网页A rapid accumulation of information on the molecular underpinnings of the excitotoxic process is leading to the development of novel therapeutic approaches for neurodegenerative disorders, as well as unexpected insight …
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