Heparin - Wikipedia
网页Heparin, also known as unfractionated heparin (UFH), is a medication and naturally occurring glycosaminoglycan. [3][4] Heparin is a blood anticoagulant that increases the activity of antithrombin. [5] It is used in the treatment of heart attacks and unstable angina. [3]
肝素 - 维基百科，自由的百科全书
网页肝素 （英文：heparin）又稱 普通肝素 、 未裂解肝素 （unfractionated heparin，UFH），是一種天然且高度硫化的 糖胺聚糖 抗凝血劑 [3][4]，也是所有生物分子中陰電密度最高的分子 [5]，平均分子量约15,000 道尔顿。. 肝素可用來治療及預防 深靜脈血栓 、 肺栓塞 、 動脈 ...
Isolation, Purification, and Characterization of Heparinase from
网页2019年4月24日 · The total heparinase production was higher for the intracellular enzyme (41.04 U/L) compared to the extracellular enzyme (34.02 U/L). A major amount of heparin was utilized in the stationary phase...
Identification and characterization of a novel heparinase ... - Nature
网页2023年11月17日 · Heparin (HP) and heparan sulfate (HS) are multifunctional polysaccharides widely used in clinical therapy. Heparinases (Hepases) are enzymes that specifically catalyse HP and HS degradation,...
Heparin: Uses, Interactions, Mechanism of Action - DrugBank Online
网页Generic Name Heparin DrugBank Accession Number DB01109 Background. Unfractionated heparin (UH) is a heterogenous preparation of anionic, sulfated glycosaminoglycan polymers with weights ranging from 3000 to 30,000 Da.
Heparinase II from Flavobacterium heparinum - Journal of …
网页The three heparinases derived from Flavobacterium heparinum are powerful tools for studying heparin-like glycosaminoglycans in major biological processes, including angiogenesis and development. Heparinase II is unique among the three enzymes because it is able to catalytically cleave both heparin and heparan sulfate-like regions of heparin ...
Heparinase I from Flavobacterium heparinum - Journal of …
网页In this study we have identified the primary heparin binding site of heparinase I (EC 4.2.2.7). Chemical and proteolytic digests of heparinase I were used in direct binding and competition assays, to map the regions of heparinase I that interact specifically with heparin.
Heparinase I from Flavobacterium heparinum - Journal of …
网页Three enzymes that degrade HLGAGs (heparin and heparan sulfate), viz. heparinases I, II, and III from Flavobacterium heparinum, recognize unique sequences of sulfation and uronic acid epimerization in HLGAGs with a high degree of specificity (3-5).
Heparin/Heparan Sulfate 6- O -Sulfatase from Flavobacterium heparinum
网页2009年12月11日 · In this study, we report the molecular cloning and recombinant expression in Escherichia coli of the F. heparinum sulfohydrolase, namely the glucosamine 6-O-sulfatase, and in the accompanying manuscript we report detailed studies on the N-sulfamidase as well as a model for how the 2-O- and 6-O-sulfatases, and N-sulfamidase work in concert. In ...
Cloning, Expression, and Characterization of a Highly Stable …
网页2023年4月3日 · Heparinase I was first discovered in Flavobacterium heparinum , while it has been found to be produced by other microorganisms including several Bacteroides [17,18,19,20]. Production of native heparinase with the original bacteria is hampered by several obstacles, including variability in production [ 20 ], costly heparin-based inducers [ …
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