A multicenter phase II trial of anti-EGFR-immunoliposomes
网页2023年3月6日 · Mamot, C. et al. Immunoliposomal delivery of doxorubicin can overcome multidrug resistance mechanisms in EGFR-overexpressing tumor cells. J. Drug Target. 20 (5), 422–432 (2012).
Immunoliposomes - PubMed
网页Immunoliposomes are generated by coupling of antibodies to the liposomal surface and allow for an active tissue targeting through binding to tumor cell-specific receptors.
Immunoliposomes: A review on functionalization strategies and targets ...
网页2017年11月1日 · Immunoliposomes have been focused for cancer therapy. •. Preclinical studies evidenced selective delivery to pathologic site. •. Clinical trials are promising for cancer treatment. Abstract.
Immunoliposomes: A review on functionalization strategies and targets ...
网页2017年11月1日 · The functionalization of liposomes with monoclonal antibodies or antibody fragments to generate immunoliposomes has emerged as a promising strategy for targeted delivery to and uptake by cells overexpressing the antigens to these antibodies, with a consequent reduction in side effects.
Immunoliposomes: A Targeted Drug Delivery System for Cancer ...
网页Immunoliposomes, also known as antibody-coupled liposomes, have gained a lot of attention as a homing device for targeted therapies. Monoclonal antibodies or antibody fragments that combine with liposomes to create immunoliposomes have been considered a leading technique for targeted delivery.
Immunoliposomes as an emerging nanocarrier for breast cancer …
网页2023年2月7日 · Immunoliposomes have been suggested as a promising therapeutic delivery device for the therapy of breast cancer. In this review, we highlight current developments of immunoliposome formulation that synergistically demonstrate distinct target-cell associations while combining or loading with a variety of cytotoxic drugs. Graphical abstract.
Anti-HER2 Super Stealth Immunoliposomes for Targeted …
网页2023年8月17日 · We investigated the advantage of targeted immunoliposomes, obtained by decorating the surface of liposomes with Fab’ moieties coupled to a PEG spacer bearing a phospholipid moiety for the anchoring to the phospholipid bilayer (Figure 1A).
ROR1 Targeted Immunoliposomal Delivery of OSU-2S Show …
网页2019年11月13日 · The receptor tyrosine kinase ROR1 is uniquely expressed on and required for many hematological malignancies such as t (1;19) positive acute lymphoblastic leukemia (ALL) and chronic lymphocytic leukemia (CLL). The t (1;19) is one of the most frequent translocations in B-ALL, observed in both adult and pediatric patients.
Immunoliposomal Delivery of Mir-29b By Targeting Tumor …
网页2015年12月3日 · Immunoliposomal Delivery of Mir-29b By Targeting Tumor Antigen ROR1 Induces Epigenetic Reprograming in Human-ROR1-Expressed Mouse Model of Chronic Lymphocytic Leukemia. Chi-Ling Chiang, Frank W Frissora, Zhiliang Xie, Xiaomeng Huang, Rajeswaran Mani, DVM, Sivasubramanian Baskar, Christoph Rader, Kenneth K. Chan, Guido Marcucci, MD,
The use of single chain Fv as targeting agents for immunoliposomes…
网页ScFv is potentially a useful targeting agent for immunoliposomal drugs and hopefully this paper can help to point the direction for the future development of clinically acceptable immunoliposomal anticancer therapies.