Mucokinetics - an overview | ScienceDirect Topics
网页Acetylcysteine 10% (Mucomyst) is an effective mucolytic. The mechanism of action is lysis of the disulfide bonds in mucopolysaccharide chains, reducing the viscosity of the mucus. The indication is for management of viscous, inspissated, mucopurulent secretions.
网页The History of Pharmacokinetics. THE ORIGINS OF PHARMACOKINETICS were both multina-tional and multidisciplinary. From Germany, in 1913, Michaelis and Menten,1 a man and woman respectively, gave us what is now known as the "Michaelis-Menten equation" for enzyme kinetics. This equation is used in explaining the elimina-tion kinetics of ethanol ...
Pharmacokinetics - Latest research and news | Nature
网页2024年8月28日 · Pharmacokinetics is an area of pharmacology concerned with the time course of absorption, distribution, metabolism and excretion (collectively ADME) of drugs from biological systems in order...
Mucoactive agent - Wikipedia
网页Mucoactive agents are a class of chemical agents that aid in the clearance of mucus or sputum from the upper and lower airways, including the lungs, bronchi, and trachea. Mucoactive drugs include expectorants, mucolytics, mucoregulators, and mucokinetics.
Pharmacokinetics - PubMed
网页2023年7月30日 · Pharmacokinetics (PK) is the study of how the body interacts with administered substances for the entire duration of exposure (medications for the sake of this article). This is closely related to but distinctly different from pharmacodynamics, which examines the drug’s effect on the body more close ….
Pharmacogenomics, Pharmacokinetics, and Pharmacodynamics in …
网页2016年5月19日 · Pharmacogenomic analysis of tumor tissue is an important tool in identifying therapies that will be effective against certain cancers while also preventing patients for whom these therapies are unlikely to be effective from suffering the physical and economic toxicities inherent to each treatment.
Mucolytics, expectorants, and mucokinetic medications
网页Mucoactive medications include expectorants, mucolytics, and mucokinetic drugs. Expectorants are meant to increase the volume of airway water or secretion in order to increase the effectiveness of cough.
Monoclonal antibody pharmacokinetics and pharmacodynamics
网页More than 20 monoclonal antibodies have been approved as therapeutic drugs by the US Food and Drug Administration, and it is quite likely that the number of approved antibodies will double in the next 7-10 years. Antibody drugs show several desirable characteristics, including good solubility and stability, long persistence in the body, high ...
A Systems Approach for Tumor Pharmacokinetics - PLOS
网页2011年9月14日 · The pharmacokinetics (PK) of a drug or imaging agent is a major determinant of its utility and efficacy in the clinic. Despite its importance, poor drug distribution and overall tumoral uptake is often neglected as a mechanism of drug resistance in cancer [1] and becomes even more complicated in multidrug regimens [2].
Ceftobiprole: pharmacokinetics and PK/PD profile - PMC
网页2019年9月4日 · Ceftobiprole, a beta-lactam antibiotic belonging to the cephalosporin group, is the latest inclusion into the select group of active drugs against these types of bacteria, hence the interest in practically describing the primary pharmacokinetic and pharmacokinetic/pharmacodynamic (PK/PD) characteristics in order to achieve more efficient use of ...