A lysosome-targeted DNA nanodevice selectively targets ... - Nature
网页2021年11月11日 · We developed a DNA nanodevice (E64-DNA) that targets the lysosomes of TAMs in mice. E64-DNA inhibits the population of cysteine proteases that is present specifically inside the lysosomes of...
Nanodevices for cancer vaccination | Nature Materials
网页2021年2月25日 · In this issue of Nature Materials, Baoquan Ding and colleagues developed a cancer vaccine based on a DNA-based nanodevice that can be efficiently transported to draining lymph nodes (dLNs) and is...
Nanodevice - an overview | ScienceDirect Topics
网页Nano refers to characterization of parts measured in nanometers. Nanodevices can be designed by computer software, such as MATLAB® and Nanoxplorer. Nanoxplorer works with collections of different hierarchical components, nanosystems, connections, molecular devices, and interfaces to develop nanodevices.
An intelligent DNA nanodevice for precision thrombolysis
网页2024年3月6日 · An intelligent DNA nanodevice, composed of DNA origami nanosheets and a thrombin-responsive DNA fastener, accurately delivers the appropriate dose of tissue plasminogen activator following ...
An orthogonally regulatable DNA nanodevice for …
网页2020年6月17日 · We demonstrated that orthogonal regulation endows the nanodevice with spatiotemporal-controlled biorecognition, enhanced tumor specificity, and robust antitumor efficacy. Furthermore, the nanodevice generated an immunogenic tumor microenvironment and significantly improved the efficacy of immune checkpoint blockade therapy.
A Redox-Activatable DNA Nanodevice for Spatially-Selective, …
网页2021年11月22日 · The DNA nanodevice was designed by the controlled assembly of the redox-responsive ATP aptamer probe on the nanoparticles and further decorated with mitochondria-targeting signals. We demonstrate that the system allows for mitochondria-specific, correlated imaging of ATP and GSH in living cells and in vivo.
A Tubular DNA Nanodevice as a siRNA/Chemo‐Drug Co‐delivery …
网页2020年10月21日 · An autonomous tubular DNA nanodevice is constructed to deliver a chemotherapeutic drug and siRNAs. This nanodevice can realize on-demand targeting, respond to stimuli in the intracellular environment and release multiple molecular payloads for combined antitumor activity.
DNA Nanodevices: From Mechanical Motions to Biomedical
网页Inspired by molecular machines in nature, artificial nanodevices have been designed to realize various biomedical functions. Self-assembled deoxyribonucleic acid (DNA) nanostructures that feature designed geometries, excellent spatial accuracy, nanoscale addressability, and marked biocompatibility p ….
CytoDirect: A Nucleic Acid Nanodevice for Specific and Efficient ...
网页2023年12月6日 · Here, we take advantage of the programmability of DNA nanotechnology to develop a DNA nanodevice called CytoDirect, which incorporates disulfide units and human epidermal growth factor receptor 2 (HER2) affibodies into a DNA origami nanostructure, enabling rapid cytosolic uptake into targeted cancer cells and deep tissue penetration.
Nanodevices for Biological and Medical Applications: …
网页2022年1月31日 · This review provides information on the current status and future prospects of nanodevice-based single-molecule electrical measurement technology, which is making a full-scale contribution to realizing personalized medicine in the future.
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