Pyrazolone - Wikipedia
网页Pyrazolone is 5-membered heterocycle containing two adjacent nitrogen atoms. It can be viewed as a derivative of pyrazole possessing an additional carbonyl (C=O) group. Compounds containing this functional group are useful commercially in analgesics and dyes.
Pyrazolone structural motif in medicinal chemistry: Retrospect …
网页2020年1月1日 · The pyrazolone structural motif is a critical element of drugs aimed at different biological end-points. Medicinal chemistry researches have synthesized drug-like pyrazolone candidates with several medicinal features including antimicrobial, antitumor, CNS (central nervous system) effect, anti-inflammatory activities and so on.
A critical review on recent trends on pharmacological applications …
网页2022年8月15日 · Pyrazolone, featuring a five-membered ring with nitrogen–nitrogen bond and an additional ketonic group (C=O) is considered as one of the important heterocyclic compounds owing to their widespread presence in medical chemistry [13].
New pyrazolone derivatives, synthesis, characterization, and ...
网页2022年1月14日 · New derivatives of the pyrazolone nucleus were synthesized, characterized, and evaluated by spectroscopic analysis including FT-IR (with a prominent peak at 2922 (C-H str, CH)), 1 HNMR, and 13 C NMR. Elemental analysis, M.W, M.P, and R f values were also carried out.
Pyrazoles and Pyrazolines as Anti-Inflammatory Agents
网页2021年6月5日 · Pyrazole is a versatile lead molecule; its derivatives are reported to possess innumerable biological activities such as anti-microbial, anti-fungal, anti-tubercular, anti-inflammatory, anti-convulsant, anticancer, anti-viral, angiotensin converting enzyme (ACE) inhibitory, neuroprotective, cholecystokinin-1 receptor antagonist, and estrogen rec...
Pyrazolone - an overview | ScienceDirect Topics
网页2003年7月5日 · The pyrazolone structural motif is a critical element of drugs aimed at different biological end-points. Medicinal chemistry researches have synthesized drug-like pyrazolone candidates with several medicinal features including antimicrobial, antitumor, CNS (central nervous system) effect, anti-inflammatory activities and so on.
Pyrazolone | C3H2N2O | CID 11513733 - PubChem
网页Anti-inflammatory agents that are non-steroidal in nature. In addition to anti-inflammatory actions, they have analgesic, antipyretic, and platelet-inhibitory actions. They act by blocking the synthesis of prostaglandins by inhibiting cyclooxygenase, which converts arachidonic acid to cyclic endoperoxides, precursors of prostaglandins.
Pyrazolones - an overview | ScienceDirect Topics
网页Pyrazolones are a group of organic compounds that have been extensively studied for their properties and applications, particularly their analgesic, antipyretic, and anti-inflammatory effects. They have been used in the past for the treatment of humans but due to their toxic effects, their use is now limited to the veterinary field.
Pyrazolone | drug | Britannica
网页use as analgesic. In analgesic: Anti-inflammatory analgesics. …in the 19th century—salicylic acid, pyrazolone, and phenacetin (or acetophenetidin). Although chemically unrelated, the drugs in these families have the ability to relieve mild to moderate pain through actions that reduce inflammation at its source.
Pyrazole: An Important Core in Many Marketed and Clinical Drugs
网页Pyrazolone drugs are primarily used as antipyretic analgesics. However, they are progressively being phased out of the market due to their adverse effects and the discovery of alternative therapies.
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