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网页2024年8月20日 · eLife is a non-profit organisation inspired by research funders and led by scientists. Our mission is to help scientists accelerate discovery by operating a platform for research communication that encourages and recognises the most responsible behaviours in science. eLife Sciences Publications, Ltd is a limited liability non-profit non-stock …
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网页2019年3月11日 · eLife is a non-profit organisation inspired by research funders and led by scientists. Our mission is to help scientists accelerate discovery by operating a platform for research communication that encourages and recognises the most responsible behaviours in science. eLife Sciences Publications, Ltd is a limited liability non-profit non-stock …
Science Forum: SARS-CoV-2 (COVID-19) by the numbers - eLife
网页2020年3月31日 · Abstract. The COVID-19 pandemic is a harsh reminder of the fact that, whether in a single human host or a wave of infection across continents, viral dynamics is often a story about the numbers. In this article we provide a one-stop, curated graphical source for the key numbers (based mostly on the peer-reviewed literature) about the …
Reviewed Preprints - eLife
网页3 天之前 · eLife is a non-profit organisation inspired by research funders and led by scientists. Our mission is to help scientists accelerate discovery by operating a platform for research communication that encourages and recognises the most responsible behaviours in science. eLife Sciences Publications, Ltd is a limited liability non-profit non-stock …
Translation affects mRNA stability in a codon-dependent manner …
网页2019年4月23日 · To determine whether codon composition affects mRNA stability in human cells, we treated 293T, HeLa and RPE cells with Actinomycin D to block transcription (Figure 1—figure supplement 1A) and measured decay of existing mRNAs by performing time-course mRNA-seq ().We calculated the codon stability coefficient (CSC) as the Pearson …
Mitochondrial fusion supports increased oxidative ... - eLife
网页2019年1月29日 · Despite an increase in glycolysis, however, here we show that non-transformed mouse fibroblasts also increase oxidative phosphorylation (OXPHOS) by nearly two-fold and mitochondrial coupling efficiency by ~30% during proliferation. Both increases are supported by mitochondrial fusion. Impairing mitochondrial fusion by knocking down …
In vivo proteomic mapping through GFP-directed proximity ... - eLife
网页2021年2月16日 · We first tested the ability of a number of biotin ligases to catalyse protein biotinylation in live zebrafish embryos. Initial attempts using BirA* or BioID2 biotin ligases in vivo in zebrafish were unsuccessful and resulted in no detectable biotinylation in zebrafish embryos as assessed by streptavidin western blotting (Figure 1—figure supplement 1).
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Human DECR1 is an androgen-repressed survival factor that ... - eLife
网页2020年7月20日 · Prostate cancer (PCa) is the most prevalent male cancer and the second leading cause of cancer deaths in men in Western societies (Bray et al., 2018).For patients with locally-recurrent and/or metastatic disease, androgen deprivation therapy (ADT) has remained the frontline strategy for clinical management since the 1940s (Huggins and …
Maternal obesity may disrupt offspring metabolism by inducing …
网页2024年8月13日 · Abstract. Maternal obesity has deleterious effects on oocyte genome methylation establishment, yet the underlying mechanisms remain unclear. In the present study, we first find that maternal obesity induced by high-fat diet (HFD) disturbs genomic methylation in oocytes, and at least a part of the altered methylation is transmitted to F2 …