Tribendimidine - Wikipedia
网页Tribendimidine is a broad-spectrum anthelmintic agent developed in China, at the National Institute of Parasitic Diseases in Shanghai. It is a derivative of amidantel. [1] In clinical trials, it was highly effective in treating ankylostomiasis, ascariasis and enterobiasis. [2] It is also effective against clonorchiasis. [3]
Tribendimidine: great expectations - The Lancet Infectious Diseases
网页2016年7月26日 · Tribendimidine is the first new chemotherapeutical antiparasitic drug to appear within the past 30 years and has a broad spectrum of activity against 20 different worm infections, including Taenia spp and the world's most common intestinal nematodes, such as Ascaris lumbricoides, hookworms, and Trichuris trichiura. 2 Importantly, the drug is ...
Tribendimidine - an overview | ScienceDirect Topics
网页Tribendimidine, a symmetrical diamidine derivative of amidantel, is a broad-spectrum anthelminthic drug, developed in China in the mid-1980s [39]. The chemical structure of tribendimidine is shown in Figure 1.
Tribendimidine: an alternative to praziquantel to treat human …
网页2017年11月16日 · Tribendimidine is an amidantel derivative acting on L-subtype nicotinic acetylcholine receptors, first discovered and developed in China more than 30 years ago. 8 Tribendimidine has broad-spectrum activity against intestinal nematodes, and the Chinese Food and Drug Administration approved this drug for …
The New Anthelmintic Tribendimidine is an L-type (Levamisole …
网页2009年8月11日 · In the past 30 years, only one new anthelmintic to treat human HAT infections has reached the clinic, tribendimidine. Tribendimidine, a symmetrical diamidine derivative of amidantel, is a broad-spectrum anthelmintic drug developed by the Chinese National Institute of Parasitic Diseases during the 1980s .
Efficacy and safety of tribendimidine, tribendimidine plus …
网页The results from this randomised, controlled, single blinded, non-inferiority trial confirmed the good safety profile of tribendimidine, with only a few and mainly mild adverse events reported. The efficacy profile of tribendimidine resembles albendazole, the current standard drug against hookworm infections.
Tribendimidine: a promising, safe and broad-spectrum …
网页2005年4月1日 · We review, for the first time, a 20-year Chinese story of research and development pertaining to tribendimidine, a promising anthelmintic agent that is safe and exhibits a broad spectrum of activity. Tribendimidine was first synthesized at the National Institute of Parasitic Diseases in Shanghai in the mid 1980s.
Tribendimidine: A promising, safe and broad-spectrum
网页2005年4月1日 · Tribendimidine is considered a promising and safe anthelmintic prodrug, identified and developed in China, with broad-spectrum activity against several nematodes and the liver flukes Clonorchis...
Tribendimidine: Mode of Action and nAChR Subtype Selectivity in
网页2015年2月13日 · Tribendimidine was developed in China in the mid-1980s as a broad spectrum anthelmintic against soil-transmitted nematodes. Its mode of action has been investigated molecularly in C. elegans and on expressed nAChRs but, its mode of action has not been investigated directly in parasitic nematodes.
Tribendimidine: a promising, safe and broad-spectrum …
网页2005年4月1日 · Tribendimidine was first synthesized at the National Institute of Parasitic Diseases in Shanghai in the mid 1980s. In laboratory studies, tribendimidine showed …