A thermostable, closed SARS-CoV-2 spike protein trimer
网页2020年7月22日 · Metrics. Abstract. The spike (S) protein of SARS-CoV-2 mediates receptor binding and cell entry and is the dominant target of the immune system. It exhibits substantial conformational flexibility.
Stabilizing the closed SARS-CoV-2 spike trimer - Nature
网页2021年1月11日 · The trimeric spike (S) protein of SARS-CoV-2 is the primary focus of most vaccine design and development efforts. Due to intrinsic instability typical of class I fusion proteins, S tends...
A self-assembled trimeric protein vaccine induces protective …
网页2022年9月17日 · Metrics. The recently emerged Omicron (B.1.1.529) variant has rapidly surpassed Delta to become the predominant circulating SARS-CoV-2 variant, given the higher transmissibility rate and immune...
Conformational dynamics of SARS-CoV-2 trimeric spike ... - Science
网页The SARS-CoV-2 trimeric spike (S) glycoprotein interacts with the human ACE2 receptor to mediate viral entry into host cells. We report the cryo-EM structures of a tightly closed SARS-CoV-2 S trimer with packed fusion peptide and an ACE2-bound S trimer at 2.7- and 3.8-Å resolution, respectively.
Studies on synthesis of andrographolide trimaleic acid monoester …
网页2005年4月1日 · OBJECTIVE: To synthesize andrographolide trimaleic acid monoester (ATME) and study its antipyretic and anti-inflammatory activity. METHODS: The target compound was prepared from andrographolide...
Cell signalling: 3.2 Trimeric G proteins - OpenLearn
网页Trimeric G proteins interact with 7TM receptors and are all heterotrimeric, having structurally different α, β and γ subunits. Monomeric G proteins are the small G proteins, such as Ras, which are structurally related to the α subunit of trimeric G proteins.
Studies on synthesis of andrographolide trimaleic acid monoester …
网页Abstract OBJECTIVE To synthesize andrographolide trimaleic acid monoester(ATME) and study its antipyretic and anti-inflammatory activity. METHODS The target compound was prepared from andrographolide and maleic anhydride.
Trimer (chemistry) - Wikipedia
网页In chemistry, a trimer (/ ˈtraɪmər /; from Ancient Greek tri- 'three' and -mer 'parts') is a molecule or polyatomic anion formed by combination or association of three molecules or ions of the same substance. In technical jargon, a trimer is a kind of oligomer derived from three identical precursors often in competition with polymerization.
Trimeric Architecture Ensures the Stability and Biological Activity of ...
网页2023年1月21日 · Introduction. In some oligomeric proteins, subunits must be assembled before the protein becomes functional. For example, this is the case for enzymes that have a catalytic site located at the interface between neighbouring subunits, …
PMMA thermoreversible networks by Diels–Alder reaction
网页2013年5月1日 · First, a trimaleic acid is obtained after reaction between a triamine (Jeffamine T403) and maleic anhydride. Then, the acid is dehydrated in order to obtain the maleimide function. Download : Download full-size image