The findings offer a promising drug target to prevent progression to colon cancer by targeting abnormal cells early on.

New research highlights a pivotal role for the p53 gene in ulcerative colitis progression, offering a potential therapeutic ...

Researchers in the lab of Michael Sigal at the Max Delbrück Center and Charité – Universitätsmedizin Berlin have elucidated ...

Results provide a mechanistic explanation of why early loss of p53 signaling is frequently observed in UC-associated ...

The study emphasises on the role of the p53 tumor suppressor gene in the pathogenesis of ulcerative colitis - an inflammatory bowel disease.

In a recent perspective published in the journal Cell Death and Differentiation, researchers in France, Germany, and Sweden ...

p53 is a common denominator among human cancers. How was it discovered? What are the persistent questions about its function? Aa Aa Aa It seems nearly impossible for a normal cell to become a ...

It causes mutations in the p53 tumor-suppressor gene as well as ras mutations, which are involved in the majority of human cancers. Aflatoxin has been shown to contaminate tobacco products.

Metabolic dysfunction-associated steatotic liver disease (MASLD) and its more advanced form, metabolic dysfunction-associated ...

Presentation Details: Title: CLSP-1025, a novel bispecific T cell engager targeting a p53 R175H mutant peptide presented by HLA-A*02:01 Presentation Type: Poster Abstract Number: 1061 Date and ...

德国Max delbrck中心Michael Sigal实验室和柏林慈善医院的研究人员在《科学进展》杂志上发表了一项研究结果，阐明了p53基因在溃疡性结肠炎中的作用，提出了一种潜在的新药靶点，可以阻止疾病发展为癌症。

In the presentation titled, "Oncogenic human papillomavirus hijacks p300 to drive viral transcription, creating a therapeutic vulnerability that can be exploited with selective p300/CBP catalytic ...