谈及癌症转移，一句话总结就是一个巴掌拍不响。这是纪念斯隆-凯特琳癌症中心（MSK）研究人员领导的一项新研究的主要发现之一：TGF-β和RAS信号通路共同促进了肺腺癌的扩散，而肺腺癌是全球癌症死亡的主要原因。近日，一篇发表在国际杂志 Cell 上题为 “TGF-β and RAS jointly unmask primed enhancers to drive metastasis” ...

A research team identified Ru5 as a potent antitumor agent by screening a panel of ruthenium(II) polypyridine complexes ...

GlobalData’s report assesses the drugs in the Copper Transporting ATPase 2 pipeline by therapy areas, indications, stages, MoA, RoA, molecule type and the key players in the development pipeline.

作者通过质谱筛选和生物信息学分析，发现了TFEB的激活是STING的一个全新重要功能，确认了这一功能在不同物种中的高度保守性，揭示了STING的质子通道功能在TFEB激活中的核心作用，阐明了非经典自噬中的GABARAP脂质化是STING-TFEB通路 ...

SPR720 is an oral, chemically stable phosphate ester prodrug that is converted rapidly in vivo to SPR719, the active moiety. SPR719 targets the ATPase site of DNA gyrase B in mycobacteria, a mechanism ...

Darier disease (DD) is a rare cutaneous disease caused by heterozygous mutations in the ATP2A2 gene, which encodes sarco/endoplasmic reticulum calcium ATPase isoform 2 (SERCA2).

宾夕法尼亚州WARRINGTON - 生物技术公司Windtree Therapeutics, Inc. (NASDAQ:WINT)今天宣布,其istaroxime药物的2b期SEISMiC延伸研究达到了主要终点,在6小时内显著改善了由心力衰竭引起的早期心源性休克患者的收缩压。该研究还报告了有利的次要结果和一致的安全性特征。 SEISMiC延伸研究覆盖美国、欧洲和拉丁美洲,重点研究istaroxi ...

NAFLD严重危害国人身心健康，然而，肝脏甘油三酯沉积的原因和机制仍不清楚。 研究团队通过分析NAFLD动物模型的基因表达谱发现去泛素化酶RPN11（Regulatory particle non-ATPase 11）的表达显著上调，并且与脂肪酸含量密切相关。进一步利用肝脏特异性基因敲除小鼠和 ...

University of Galway will lead a new research project aimed at understanding the development of neurodegenerative diseases.

Propranolol reduces experimental murine cerebral cavernous malformations (CCMs) and prevents embryonic caudal venous plexus (CVP) lesions in zebrafish that follow mosaic inactivation of ccm2. Because ...