The allele frequency represents the incidence of a gene variant in a population. Alleles are variant forms of a gene that are located at the same position, or genetic locus, on a chromosome.

Current techniques have their roots in allele-specific oligonucleotide hybridization (ASOH) 1. In its basic form (i.e., hybridization, stringent washing, and signal detection), ASOH is limited by ...

The association between the HLA-DRB1*01:03 allele and ulcerative colitis has been noted previously, but there is a clinical need for biomarkers that could identify which patients are more likely ...

Researchers found that a chromosome 6 locus within the HLA region was significantly associated with severe vs less severe ulcerative colitis.

The HLA-DRB1*01:03 allele explained this association overall (OR 3.32, 95% CI 2.25-4.89, P=1.45 × 10-9) and in the two ...

Finally, turning to WVE-003, our first in class allele selective oligonucleotide for the treatment of HD. In June, we shared ...

"I think in medicine, just like in society, we see death as a failure -- and we do everything we can to avoid failure." -- ...

A fatal, highly hereditary illness with no disease-modifying treatments, Huntington’s is long overdue for a therapeutic win.

The study identifies links between gut microbiota, genetic variants in IBD, and mental health disorders, offering insights ...

Researchers have discovered that a gene variant, KIR3DL1*114, linked to Denisovans, may impact the immune response in First ...

Related Behaviors and Risk of Common Age-Related Brain Diseases Across Severities of Genetic Risk," published in the November ...

With Eisai and Biogen’s Leqembi and Eli Lilly’s Kisunla launching onto the market, the 2024 Clinical Trials of Alzheimer’s ...