The allele frequency represents the incidence of a gene variant in a population. Alleles are variant forms of a gene that are located at the same position, or genetic locus, on a chromosome.

The association between the HLA-DRB1*01:03 allele and ulcerative colitis has been noted previously, but there is a clinical need for biomarkers that could identify which patients are more likely ...

Researchers found that a chromosome 6 locus within the HLA region was significantly associated with severe vs less severe ulcerative colitis.

The past four years have brought disappointment for the Huntington’s community, but optimism is growing as companies ...

A fatal, highly hereditary illness with no disease-modifying treatments, Huntington’s is long overdue for a therapeutic win.

Genes come in different varieties, called alleles. Somatic cells contain two alleles for every gene, with one allele provided by each parent of an organism. Often, it is impossible to determine ...

"I think in medicine, just like in society, we see death as a failure -- and we do everything we can to avoid failure." -- ...

Related Behaviors and Risk of Common Age-Related Brain Diseases Across Severities of Genetic Risk," published in the November ...

Researchers have discovered that a gene variant, KIR3DL1*114, linked to Denisovans, may impact the immune response in First ...

Finally, turning to WVE-003, our first in class allele selective oligonucleotide for the treatment of HD. In June, we shared ...

The study identifies links between gut microbiota, genetic variants in IBD, and mental health disorders, offering insights ...

The HLA-DRB1*01:03 allele explained this association overall (OR 3.32, 95% CI 2.25-4.89, P=1.45 × 10-9) and in the two ...