药品分类：抗肿瘤药物非小细胞肺癌（NSCLC）是全球范围内常见且治疗难度较大的一种癌症类型。针对这种疾病的治疗，科学家们一直在寻求更有效的治疗方案。氟泽雷塞片（商品名：达伯特），一种革命性的口服靶向药物，专门针对KRAS ...

Pacritinib，商品名为Vonjo，是一种用于治疗骨髓纤维化的抗癌药物。它是一种大环蛋白激酶抑制剂。它主要抑制Janus 激酶 2 (JAK2) 和Fms 样酪氨酸激酶 3\CD135 (FLT3)。

Scientists have always been fascinated by how our bodies work and how the world around us affects us. Recently, a team from ...

In general, those with variations affecting the genes – namely CYP1A2 and a gene that regulates it, called AHR – tend to ...

After a person quits smoking, an important consideration is how quickly the induction of CYP1A2 dissipates. The primary pharmacokinetic interactions with smoking occur with drugs that are CYP1A2 ...

但是，咖啡因的影响并不是人人相同。基因类型如CYP1A2或PDSS2的差异会影响个体对咖啡因的敏感性和代谢速度。此外，长期大量饮用咖啡，可能会使 ...

2. 罗红霉素：属大环内酯类抗菌药物，可抑制CYP3A4和CYP1A2的活性。当罗红霉素与氨茶碱合用时，罗红霉素可抑制氨茶碱的代谢，升高氨茶碱血药浓度 ...

Caffeine's stimulating effects can paradoxically lead to sleepiness due to tolerance, adenosine receptor changes, and individual metabolic differences.

Dr Grimaldi says if you carry the genetic variation CYP1A2 (AA), for example, you will “almost certainly” metabolise caffeine faster than someone who doesn’t, and therefore feel its effects ...

Figure 1 lists the pharmacokinetic drug interactions with smoking. The most clinically significant interactions appear in the shaded rows and are discussed below.