Molecular chaperones have long been heralded as machines for folding and salvaging proteins. However, not every attempt to fold or refold a protein can be successful. Chaperones are known to ...

The cholera holotoxin, produced by Vibrio cholerae, consists of B-chain subunits bound to an A1 and A2 chain, which in turn are joined by disulphide bonds. Upon uptake by a host cell, the ...

Therefore, cells have mechanisms in place to control protein quality. In animal and human cells, chaperones of the Hsp70 class are at the heart of this control system, overseeing a wide array of ...

Our research focuses on studies on the molecular structure and mechanism of proteins, recently mostly on the endoplasmic reticulum proteins involved in cellular stress signalling, including in ...

A new review was published in Oncotarget's Volume 15 on October 1, 2024, entitled, "Molecular chaperones: Guardians of tumor ...