The chaperones Hsp70 and Hsp90 cooperate in the folding and maturation of a subset of proteins that includes protein kinases, steroid hormone receptors (such as the glucocorticoid receptor), and ...

The balance of protein folding and degradation is one of the most fundamental activities of the cell, and is a critical point of intervention in cancer, metabolic, and aging diseases. Molecular ...

Therefore, cells have mechanisms in place to control protein quality ... Among their several roles, chaperone proteins like Hsp70s typically assist the correct folding of proteins.

Researchers identified a non-genetic mechanism at the base of this new multicellular trait, which acts at the level of ...

The researchers examined the chaperone HSP90, responsible for helping to fold ... Until now, researchers have focused their efforts on designing drugs to block CDC37’s role in protein folding by ...

Heat shock proteins (HSPs) are the chaperones of cellular stress response because they help guide the folding and unfolding of other proteins ... Humans possess up to 17 variations of this protein, ...