Changes in this cartilage are part of what can happen when someone has osteoarthritis. Chondrocytes are the cells that make up cartilage and help maintain the extracellular matrix. In ...

Metabolic rewiring is essential for osteoclast differentiation and bone resorption. This study shows that glutaminolysis ...

Stem cell transplantation offers promising solutions for tissue regeneration and age-related degeneration, despite challenges ...

Unlike other connective tissues, cartilage does not contain blood vessels. The chondrocytes are fed by diffusion, helped by the pumping action generated by compression of the articular cartilage ...

Several lines of evidence both from experimental models and from clinical studies reveal that TNF-like ligand 1A (TL1A) and its interaction with death receptor 3 (DR3) is critically involved in ...

Experiencing age-related diseases such as stroke, osteoarthritis, and diabetes can be profoundly challenging. Current ...

The U.S. Food and Drug Administration (FDA) has approved a request for a supplemental Biologics License Application for the repair of knee cartilage defects using arthroscopic delivery of the ...

The researchers found in test tube experiments this hybrid material supported chondrogenic differentiation – that is, the ...

Lin Han obtained his BE degree from Tsinghua University in Beijing, P. R. China, and his PhD degree from the Massachusetts Institute of Technology in the area of Bio- and Polymeric Materials. After ...

Chondrocyte columns, which are a hallmark of growth plate architecture, play a central role in bone elongation. Columns are formed by clonal expansion following rotation of the division plane, ...