Rec8 joins the whole length of the sister chromatids together, and, as meiosis proceeds, is lost in a stepwise manner that correlates with the loss of sister-chromatid cohesion. Figure 1 ...

Each chromosome is, at this time, actually two identical copies. Each copy is called a chromatid. A spindle begins to form from the centrioles. This spindle is made of fibers. The centrioles begin ...

Science DNA breaks are toxic lesions for the cell. In order to repair these breaks, it is necessary, starting from the break ends, to find a homologous sequence within the vastness of the genome. In ...

2012). We are now extending this approach to numerous other kinases, using both AAV vector technology and CRISPR/Cas9 RNA-guided nucleases. Establishing Sister Chromatid Cohesion during DNA ...

We have established that the S. cerevisiae Mre11 complex is critical in particular phases of the cell cycle in controlling the dynamics of chromatid interaction during double-strand break repair. This ...

This rigorous and practical account of the interpretation of mutagenicity test data draws upon the expertise of toxicologists and statisticians. Chemicals, such as drugs, food additives and pesticides ...