Science DNA breaks are toxic lesions for the cell. In order to repair these breaks, it is necessary, starting from the break ends, to find a homologous sequence within the vastness of the genome. In ...

In contrast to cohesin, which binds two sister chromatids together, condensin is thought to bind a single chromatid at multiple spots, twisting the chromatin into a variety of coils and loops ...

Each chromosome is, at this time, actually two identical copies. Each copy is called a chromatid. A spindle begins to form from the centrioles. This spindle is made of fibers. The centrioles begin ...

During anaphase II, microtubules from each spindle attach to each sister chromatid at the kinetochore. The sister chromatids then separate, and the microtubules pull them to opposite poles of the ...

Establishing Sister Chromatid Cohesion during DNA Replication Another area of emphasis is the problem of how sister chromatids are paired during their synthesis at the replication fork. This process, ...

We have established that the S. cerevisiae Mre11 complex is critical in particular phases of the cell cycle in controlling the dynamics of chromatid interaction during double-strand break repair. This ...

This rigorous and practical account of the interpretation of mutagenicity test data draws upon the expertise of toxicologists and statisticians. Chemicals, such as drugs, food additives and pesticides ...