Dual antiplatelet therapy with clopidogrel and aspirin can benefit patients with mild ischemic stroke when initiated up to 72 hours after symptom onset.

Clopidogrel is a generic prescription oral tablet that’s used to lower the risk of stroke and heart attack in certain adults. The drug is also available as the brand-name drug Plavix.

No matter whether patients had CAD or not, the simpler regimen was linked to less mortality and major bleeding at 6 months.

Since clopidogrel is a prodrug that must be converted into an active metabolite by the cytochrome P450 2C19, patients who are carriers of CYP2C19 loss-of-function genetic variants are more prone ...

Clopidogrel nonresponsiveness in patients undergoing percutaneous coronary intervention with stenting: a systematic review and meta-analysis. Am. Heart J. 154 , 221–231 (2007).