The company’s pipeline includes investigational, preclinical and clinical stage anti-resistance agents based on novel mechanisms of action that include efflux pump inhibition and modulation of ...

Crystal structures of a mammalian multidrug efflux pump bound to peptide inhibitors may reveal drug-binding sites. Figure 1: Ribbon renditions of the structure of P-glycoprotein embedded in a ...

The FDA informed Intercept that it is unable to approve the sNDA in its current form, consistent with the outcome of the Gastrointestinal Drugs Advisory Committee (GIDAC) meeting in September 2024. In ...

Specifically, our research focuses on nuclear receptor complexes that mediate gene regulation, membrane proteins such as drug efflux pumps and ion channels, and viruses, whose structures we have been ...

Daniel Flaherty's lab in the Department of Medicinal Chemistry and Molecular Pharmacology. Her research looks at how mutations in PorA and PorB porins and the mtr efflux pump effect the rate of ...

We have identified and developed compounds that act as bacterial efflux pump inhibitors (EPIs). Bacterial efflux is one of the primary mechanisms by which bacteria can develop resistance to current ...

Three clinical trials have examined the efficacy and safety of single dose azithromycin (30 mg/kg) in children with uncomplicated acute otitis media (AOM). In the first trial, a small pilot study ...

For example, structures called "efflux pumps" in the cell membrane allow bacterial cells to pump out antibiotics that get inside the cell. Bacterial cells can also make enzymes that chemically ...

For instance, DNA methylation may regulate genes encoding efflux pumps—proteins that expel antibiotics from the bacterial cell—and genes involved in biofilm formation, which can shield bacterial ...

This came after the drug maker Abbott presented the justification for the Phase III clinical trial waiver along with the ...

New gas boilers will be banned for most households from 2035, as the UK switches to heat pumps to help cut greenhouse gas emissions. But despite the availability of grants of £7,500 in England ...