Treg function is mainly controlled by a protein called Foxp3 that activates the expression of some genes and represses the ...

A team of scientists from the Perelman School of Medicine at the University of Pennsylvania and Aum Biotech LLC have described the development of a novel cancer immunotherapy designed to target ...

Four studies examine this question, delving deeply into the role of the transcription factor Foxp3 in governing Treg differentiation and function. Tregs play essential roles in immune homeostasis ...

For example, Foxp3-positive naïve regulatory T cells (nT regs) - which play a key role in the induction of self-tolerance and the control of autoimmunity–may account for only 0.5 percent of a sample ...

【导读】成纤维细胞以其功能多样性而闻名，在炎症和癌症中起着至关重要的作用。在这项研究中，团队对来自517个人类样本的成纤维细胞进行了全面的单细胞RNA测序分析，涵盖11种组织类型和不同的病理状态。2024年9月19日， ...

Our analysis of DNase-seq data in the T cell lineage and of Foxp3 ChIP-seq in regulatory T cells (Tregs) revealed that many Foxp3-bound loci are DNase accessible not only in Tregs but also in CD4+ T ...

The ID3 gene maintains FOXP3 expression, which is necessary for maintaining the suppressive function of regulatory T cells. The PRDM1 gene encodes the B lymphocyte–induced maturation protein–1 ...

The image below describes the main parts of both workflows on the basis of a colon sample stained with DAPI and for FOXP3, CD25 and CD4.

早在20多年前，耶鲁大学的研究人员就在人类机体中发现了一种能抑制 免疫 系统的特殊T细胞类型，后来他们发现，这些所谓的调节性T细胞当发生缺陷时就会诱发一些自身免疫性疾病，尤其是 多发性硬化 症（MS，multiple ...

Presentation Details Date and Time: Friday, September 6, 2024, 4 p.m. CET Presentation Title: CUE-401: A Novel IL-2/TGF-beta fusion protein for the induction & expansion of FOXP3+ regulatory T ...

Dodson L.F., Hawkins W.G., Goedegebuure P., Potential targets for pancreatic cancer immunotherapeutics. Immunotherapy. 2011 Apr;3(4):517-37. Lio C.W., Dodson L.F ...

Crohn's disease and ulcerative colitis are idiopathic, chronic, relapsing, inflammatory conditions that are immunologically mediated. Although their exact etiologies remain uncertain, results from ...